Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8VVT

Mammalian ribosomes bound to Anisomycin in the rotated conformation

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	L8	polymer	257	28088.9	1	UniProt (G1TT27) Pfam (PF00181) Pfam (PF03947)	Oryctolagus cuniculus (rabbit)
2	B (B)	uL3	polymer	403	46108.0	1	UniProt (G1TL06) Pfam (PF00297)	Oryctolagus cuniculus (rabbit)
3	C (C)	uL4	polymer	425	47740.6	1	UniProt (A0A5F9C3C5) Pfam (PF00573) Pfam (PF14374)	Oryctolagus cuniculus (rabbit)	60S ribosomal protein L4
4	D (D)	L5	polymer	297	34481.8	1	UniProt (G1SYJ6) UniProt (by SIFTS) (P19949)	Oryctolagus cuniculus (rabbit)
5	E (E)	L6	polymer	291	33028.3	1	UniProt (G1SKF7) Pfam (PF03868) Pfam (PF01159)	Oryctolagus cuniculus (rabbit)
6	F (F)	uL30	polymer	247	29201.8	1	UniProt (G1TUB1) Pfam (PF08079) Pfam (PF00327)	Oryctolagus cuniculus (rabbit)
7	G (G)	eL8	polymer	319	36221.5	1	UniProt (G1STW0) Pfam (PF01248)	Oryctolagus cuniculus (rabbit)
8	H (H)	uL6	polymer	192	21871.4	1	UniProt (G1SWI6) Pfam (PF00347)	Oryctolagus cuniculus (rabbit)
9	I (I)	L10	polymer	214	24643.1	1	UniProt (B7NZQ2) Pfam (PF00252)	Oryctolagus cuniculus (rabbit)
10	J (J)	L11	polymer	178	20288.5	1	UniProt (G1TUB8) Pfam (PF00281) Pfam (PF00673)	Oryctolagus cuniculus (rabbit)
11	K (L)	L14	polymer	218	23870.5	1	UniProt (G1SZ12) Pfam (PF01929)	Oryctolagus cuniculus (rabbit)
12	L (M)	L15	polymer	204	24207.3	1	UniProt (G1T0C1) Pfam (PF00827)	Oryctolagus cuniculus (rabbit)
13	M (N)	uL13	polymer	203	23533.3	1		Oryctolagus cuniculus (rabbit)
14	N (O)	uL22	polymer	184	21444.2	1	UniProt (G1TVT6) Pfam (PF00237) UniProt (by SIFTS) (G1SCJ6)	Oryctolagus cuniculus (rabbit)
15	O (P)	eL18	polymer	188	21699.7	1	UniProt (G1TFE0) Pfam (PF17135)	Oryctolagus cuniculus (rabbit)
16	P (Q)	eL19	polymer	196	23535.3	1	UniProt (G1TJR3) Pfam (PF01280)	Oryctolagus cuniculus (rabbit)
17	Q (R)	eL20	polymer	176	20827.6	1	UniProt (G1TTY7) Pfam (PF01775)	Oryctolagus cuniculus (rabbit)
18	R (S)	eL21	polymer	160	18610.0	1	UniProt (G1SHQ2) Pfam (PF01157)	Oryctolagus cuniculus (rabbit)
19	S (T)	eL22	polymer	128	14813.0	1	UniProt (G1TSG1) Pfam (PF01776)	Oryctolagus cuniculus (rabbit)
20	T (U)	L23	polymer	140	14892.5	1	UniProt (G1T6D1) Pfam (PF00238)	Oryctolagus cuniculus (rabbit)
21	U (V)	L24	polymer	157	17825.1	1	UniProt (G1SE28) Pfam (PF01246)	Oryctolagus cuniculus (rabbit)
22	V (W)	uL23	polymer	156	17768.2	1	UniProt (G1SE76) Pfam (PF03939) Pfam (PF00276)	Oryctolagus cuniculus (rabbit)
23	W (X)	L26	polymer	145	17303.4	1	UniProt (G1SQH0) Pfam (PF16906) Pfam (PF00467)	Oryctolagus cuniculus (rabbit)
24	X (Y)	L27	polymer	136	15835.8	1	UniProt (G1TXF6) Pfam (PF00467) Pfam (PF01777)	Oryctolagus cuniculus (rabbit)
25	Y (Z)	uL15	polymer	148	16620.6	1	UniProt (G1SNY0) Pfam (PF00828)	Oryctolagus cuniculus (rabbit)
26	Z (K)	eL13	polymer	211	24331.7	1	UniProt (G1TPV0)	Oryctolagus cuniculus (rabbit)
27	AA (AB)	uS2	polymer	295	32958.0	1	UniProt (G1TLT8) Pfam (PF00318) Pfam (PF16122)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein SA, 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40
28	BA (BB)	S3A	polymer	264	30002.1	1	UniProt (G1SS70) Pfam (PF01015)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S3a
29	CA (CB)	eS1	polymer	293	31327.4	1		Oryctolagus cuniculus (rabbit)
30	DA (WA)	28S rRNA	polymer	3635	1179589.9	1		Oryctolagus cuniculus (rabbit)
31	EA (XA)	5S rRNA	polymer	120	38691.9	1	GenBank (X06789.1)	Oryctolagus cuniculus (rabbit)
32	FA (YA)	5.8S rRNA	polymer	156	50157.7	1		Oryctolagus cuniculus (rabbit)
33	GA (AA)	eL29	polymer	245	26708.7	1	UniProt (G1SGR6) Pfam (PF01779)	Oryctolagus cuniculus (rabbit)
34	HA (BA)	eL30	polymer	115	12807.1	1	UniProt (G1TDL2) Pfam (PF01248)	Oryctolagus cuniculus (rabbit)
35	IA (CA)	eL31	polymer	125	14494.9	1	UniProt (G1SHG0) Pfam (PF01198)	Oryctolagus cuniculus (rabbit)
36	JA (DA)	eL32	polymer	135	15898.9	1	UniProt (G1U437) Pfam (PF01655) UniProt (by SIFTS) (G1TUN8)	Oryctolagus cuniculus (rabbit)
37	KA (EA)	eL33	polymer	110	12580.8	1	UniProt (G1SF08) Pfam (PF01247)	Oryctolagus cuniculus (rabbit)
38	LA (FA)	eL34	polymer	117	13326.1	1	UniProt (G1TXG5) Pfam (PF01199)	Oryctolagus cuniculus (rabbit)
39	MA (GA)	uL29	polymer	123	14566.6	1	UniProt (G1SIT5) Pfam (PF00831)	Oryctolagus cuniculus (rabbit)
40	NA (HA)	L36	polymer	105	12263.8	1	UniProt (G1TTQ5) Pfam (PF01158)	Oryctolagus cuniculus (rabbit)
41	OA (IA)	L37	polymer	97	11111.0	1	UniProt (U3KPD5) Pfam (PF01907)	Oryctolagus cuniculus (rabbit)
42	PA (JA)	eL38	polymer	70	8238.9	1	UniProt (G1U001) Pfam (PF01781)	Oryctolagus cuniculus (rabbit)
43	QA (KA)	eL39	polymer	51	6455.8	1	UniProt (G1TTN1) Pfam (PF00832)	Oryctolagus cuniculus (rabbit)
44	RA (LA)	eL40	polymer	102	11712.8	1		Oryctolagus cuniculus (rabbit)
45	SA (MA)	eL41	polymer	25	3473.5	1	UniProt (A0A087WNH4) Pfam (PF05162)	Oryctolagus cuniculus (rabbit)	60s ribosomal protein l41
46	TA (NA)	eL42	polymer	106	12477.0	1	UniProt (G1U344) Pfam (PF00935) UniProt (by SIFTS) (G1T040)	Oryctolagus cuniculus (rabbit)
47	UA (OA)	eL43	polymer	92	10299.4	1	UniProt (G1SY53) Pfam (PF01780)	Oryctolagus cuniculus (rabbit)
48	VA (PA)	eL28	polymer	137	15783.6	1	UniProt (G1U7L1) Pfam (PF01778)	Oryctolagus cuniculus (rabbit)
49	WA (QA)	uL10	polymer	318	34380.5	1	UniProt (G1SPK4) Pfam (PF00466) Pfam (PF17777) Pfam (PF00428)	Oryctolagus cuniculus (rabbit)
50	XA (RA)	uL3	polymer	165	17847.6	1	UniProt (G1SMR7) Pfam (PF03946) Pfam (PF00298)	Oryctolagus cuniculus (rabbit)
51	YA (v)	eukaryotic elongation factor 2	polymer	839	93391.0	1		Oryctolagus cuniculus (rabbit)
52	ZA (w)	Serpine mRNA binding protein 1	polymer	46	5206.6	1		Oryctolagus cuniculus (rabbit)
53	AB (ZA)	18S rRNA	polymer	1869	602979.1	1		Oryctolagus cuniculus (rabbit)
54	BB (DB)	uS3	polymer	243	26715.3	1	UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189)	Oryctolagus cuniculus (rabbit)
55	CB (EB)	eS4	polymer	263	29654.9	1	UniProt (G1TK17) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S4
56	DB (FB)	S5	polymer	204	22913.5	1	UniProt (G1TFM5) Pfam (PF00177)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S5
57	EB (GB)	S6	polymer	249	28751.9	1	UniProt (G1TM55) Pfam (PF01092)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S6
58	FB (HB)	S7	polymer	194	22168.9	1	UniProt (G1SVB0)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S7
59	GB (IB)	eS8	polymer	208	24263.4	1	UniProt (G1TJW1) Pfam (PF01201)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S8
60	HB (JB)	S9	polymer	194	22641.6	1	UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479)	Oryctolagus cuniculus (rabbit)	Ribosomal protein S9
61	IB (KB)	eS10	polymer	165	18933.8	1	UniProt (G1TPV3) Pfam (PF03501)	Oryctolagus cuniculus (rabbit)
62	JB (LB)	S11	polymer	158	18468.8	1	UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S11
63	KB (MB)	S12	polymer	132	14539.0	1	UniProt (G1SFR8) Pfam (PF01248)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S12
64	LB (NB)	uS15	polymer	151	17259.4	1	UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312)	Oryctolagus cuniculus (rabbit)	Ribosomal protein S13
65	MB (OB)	uS11	polymer	168	18134.0	1	UniProt (G1U472) Pfam (PF00411) UniProt (by SIFTS) (G1T1F0)	Oryctolagus cuniculus (rabbit)
66	NB (PB)	uS19	polymer	145	17049.2	1	UniProt (G1U0Q2) Pfam (PF00203)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S15
67	OB (QB)	S16	polymer	146	16477.4	1	UniProt (G1SGX4) Pfam (PF00380)	Oryctolagus cuniculus (rabbit)
68	PB (RB)	eS17	polymer	135	15552.1	1	UniProt (G1TU13) Pfam (PF00833)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S17
69	QB (SB)	uS13	polymer	152	17759.8	1	UniProt (G1TPG3) Pfam (PF00416)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S18
70	RB (TB)	eS19	polymer	145	16106.6	1	UniProt (G1TN62) Pfam (PF01090)	Oryctolagus cuniculus (rabbit)
71	SB (UB)	uS10	polymer	119	13398.8	1	UniProt (G1SIZ2) Pfam (PF00338)	Oryctolagus cuniculus (rabbit)
72	TB (VB)	eS21	polymer	83	9124.4	1	UniProt (G1TM82) Pfam (PF01249)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S21
73	UB (WB)	S15A	polymer	130	14865.6	1	UniProt (G1TG89) Pfam (PF00410)	Oryctolagus cuniculus (rabbit)	40S Ribosomal protein S15a
74	VB (XB)	uS12	polymer	143	15844.7	1	UniProt (G1SZ47) Pfam (PF00164)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S23
75	WB (YB)	eS24	polymer	130	15107.9	1	UniProt (G1T3D8) Pfam (PF01282)	Oryctolagus cuniculus (rabbit)
76	XB (ZB)	eS25	polymer	125	13776.2	1	UniProt (G1TDB3) Pfam (PF03297)	Oryctolagus cuniculus (rabbit)
77	YB (AC)	eS26	polymer	115	13047.5	1	UniProt (G1TFE8) Pfam (PF01283)	Oryctolagus cuniculus (rabbit)
78	ZB (BC)	S27	polymer	84	9480.2	1	UniProt (G1TZ76) Pfam (PF01667)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S27
79	AC (CC)	S28	polymer	69	7855.1	1	UniProt (G1TIB4) Pfam (PF01200)	Oryctolagus cuniculus (rabbit)	40S Ribosomal protein S28
80	BC (DC)	uS14	polymer	56	6690.8	1	UniProt (G1U7M4) Pfam (PF00253)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S29
81	CC (EC)	S30	polymer	133	14498.9	1	UniProt (G1T8A2) Pfam (PF00240) Pfam (PF04758)	Oryctolagus cuniculus (rabbit)	40S ribosomal protein S30
82	DC (FC)	S27A	polymer	156	18004.0	1	UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599)	Oryctolagus cuniculus (rabbit)	Ribosomal protein S27a
83	EC (GC)	RACK1	polymer	317	35115.7	1	UniProt (G1SJB4) Pfam (PF00400)	Oryctolagus cuniculus (rabbit)
84	FC (b)	Proliferation-associated protein 2G4	polymer	394	43851.9	1		Oryctolagus cuniculus (rabbit)
85	AD, AE, AF, AG, AH... (WA, FA, TB, AC, KA...)	MAGNESIUM ION	non-polymer		24.3	144	Chemie (MG)
86	FG (WA)	ANISOMYCIN	non-polymer		265.3	1	Chemie (ANM)
87	GG (WA)	SPERMIDINE	non-polymer		145.2	1	Chemie (SPD)
88	BH, CI, DH, DI, EH... (IA, AC, LA, DC, NA...)	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
89	GH (v)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)

Sequence modifications

F: 1 - 247 (UniProt: G1TUB1)

PDB	External Database	Details
Arg 61	Gly 61	conflict
Arg 93	Gly 93	conflict
Met 131	Val 131	conflict
Ile 153	Val 153	conflict

G: 1 - 319 (UniProt: G1STW0)

PDB	External Database	Details
Gly 244	Cys 244	conflict

P: 1 - 188 (UniProt: G1TFE0)

PDB	External Database	Details
Asp 4	Asn 4	conflict
Arg 14	Trp 14	conflict
Met 53	Leu 53	conflict
Arg 58	Trp 58	conflict
Arg 75	Gln 75	conflict
Ala 80	Pro 80	conflict
Val 86	Ile 86	conflict
Arg 104	His 104	conflict
Arg 110	Cys 110	conflict
Val 137	Gly 137	conflict
Gly 157	Arg 157	conflict
Arg 181	Trp 181	conflict

Q: 1 - 196 (UniProt: G1TJR3)

PDB	External Database	Details
Arg 38	Cys 38	conflict
Arg 64	Gln 64	conflict
Thr 94	Lys 94	conflict

R: 1 - 175 (UniProt: G1TTY7)

PDB	External Database	Details
Met 1	Thr 1	conflict
Pro 18	-	insertion
Thr 19	-	insertion
Pro 20	Ser 18	conflict
Cys 22	Ser 20	conflict
Arg 23	Pro 21	conflict
Thr 24	Ala 22	conflict
Ser 49	Leu 47	conflict
Gln 50	Glu 48	conflict
Arg 95	His 93	conflict
Thr 101	Ile 99	conflict
Thr 102	Met 100	conflict
Gly 104	Ser 102	conflict
Ile 126	Val 124	conflict
Ile 132	Met 130	conflict
Ser 135	Ala 133	conflict
Lys 136	Arg 134	conflict
Arg 138	Pro 136	conflict
Lys 149	Arg 147	conflict
Lys 151	Arg 149	conflict
Thr 168	Tyr 166	conflict
Thr 169	Ala 167	conflict
Phe 176	-	insertion

T: 1 - 128 (UniProt: G1TSG1)

PDB	External Database	Details
Leu 18	Val 18	conflict
Gly 32	Arg 32	conflict
Ala 36	Glu 36	conflict
Phe 39	Ser 39	conflict
Gly 54	Arg 54	conflict
Val 60	Ala 60	conflict
Ser 62	Thr 62	conflict
Leu 63	Ile 63	conflict
Arg 97	His 97	conflict
Thr 106	Ser 106	conflict
Glu 126	Asp 126	conflict

K: 1 - 211 (UniProt: G1TPV0)

PDB	External Database	Details
Ile 46	-	insertion
Ala 47	-	insertion
Pro 48	-	insertion
Arg 49	-	insertion
Pro 50	-	insertion
Ala 51	-	insertion
Ala 52	-	insertion
Gly 53	-	insertion
Pro 54	-	insertion

AB: 1 - 295 (UniProt: G1TLT8)

PDB	External Database	Details
Thr 114	Ala 114	conflict

XA: 1 - 120 (GenBank: X06789.1)

PDB	External Database	Details
U 2	N 2	conflict
C 36	N 36	conflict
U 102	N 102	conflict
U 112	N 112	conflict
U 114	N 114	conflict
U 119	C 119	conflict
U 120	N 120	conflict

JA: 1 - 70 (UniProt: G1U001)

PDB	External Database	Details
Lys 24	Asn 24	conflict

EB: 1 - 263 (UniProt: G1TK17)

PDB	External Database	Details
Gly 25	Ser 25	conflict
Arg 51	Lys 51	conflict
Thr 78	Ala 78	conflict
Val 156	Met 156	conflict

IB: 1 - 208 (UniProt: G1TJW1)

PDB	External Database	Details
Arg 47	Gly 47	conflict

TB: 1 - 145 (UniProt: G1TN62)

PDB	External Database	Details
Gly 119	Trp 119	conflict

VB: 1 - 83 (UniProt: G1TM82)

PDB	External Database	Details
Asn 3	Ser 3	conflict
Asp 4	Asn 4	conflict
Gln 33	Pro 33	conflict
Phe 50	Ser 50	conflict
Ala 75	Ser 75	conflict
Asp 76	His 76	conflict
Lys 81	Gln 81	conflict

AC: 1 - 115 (UniProt: G1TFE8)

PDB	External Database	Details
Arg 28	Cys 28	conflict
Ala 56	Val 56	conflict
Arg 109	Pro 109	conflict

Sequence viewer

Contents of the asymmetric unit

Polymers	Number of chains	84
Polymers	Total formula weight	3535573.9
Non-Polymers*	Number of molecules	155
Non-Polymers*	Total formula weight	4876.9
All*	Total formula weight	3540450.9

*Water molecules are not included.

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)