8VVM

Structure of FabS1CE1-EPR1-1 in complex with the erythropoietin receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	S1CE1 VARIANT OF FAB-EPR-1 heavy chain	polymer	224	24024.0	2		Homo sapiens
2	B, D (G, C)	S1CE1 VARIANT OF FAB-EPR-1 light chain	polymer	212	23049.5	2		Homo sapiens
3	E (I)	Erythropoietin receptor	polymer	232	25680.0	1	UniProt (P19235) Pfam (PF09067) Pfam (PF00041)	Homo sapiens (human)	EPO-R
4	F, J, L, P (A, G, B, C)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	4	Chemie (PEG)
5	G, H, M, Q (A, B, C)	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
6	I, K, N, R, S... (A, G, B, C)	CHLORIDE ION	non-polymer		35.5	7	Chemie (CL)
7	O (C)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
8	V, W (B, C)	water	water		18.0	3	Chemie (HOH)

Sequence modifications

I: 1 - 226 (UniProt: P19235)

PDB	External Database	Details
His 227	-	expression tag
His 228	-	expression tag
His 229	-	expression tag
His 230	-	expression tag
His 231	-	expression tag
His 232	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	119826.9
Non-Polymers*	Number of molecules	16
	Total formula weight	826.7
All*	Total formula weight	120653.6

*Water molecules are not included.