8VV0
CryoEM structure of human GABAA receptor pi (GABRP) in complex with GABA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Gamma-aminobutyric acid receptor subunit pi | polymer | 381 | 43285.1 | 5 | UniProt (O00591) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | GABA(A) receptor subunit pi |
| 2 | F, G, H, I, J (F, G, H, I, J) | alpha-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 5 | In PDB GlyTouCan (G08918EL) | |||
| 3 | K, M, O, R, T (A, B, C, D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 4 | L, N, P, Q, S (A, B, C, D, E) | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 5 | Chemie (ABU) |
Sequence modifications
A, B, C, D, E: 24 - 332 (UniProt: O00591)
| PDB | External Database | Details |
|---|---|---|
| Ser 406 | - | expression tag |
| Gln 407 | - | expression tag |
| Pro 408 | - | expression tag |
| Ala 409 | - | expression tag |
| Arg 410 | - | expression tag |
| Ala 411 | - | expression tag |
| Ala 412 | - | expression tag |
| Asn 413 | - | expression tag |
| Val 414 | - | expression tag |
| Asp 415 | - | expression tag |
| His 416 | - | expression tag |
| Tyr 417 | - | expression tag |
| Ser 418 | - | expression tag |
| Lys 419 | - | expression tag |
| Leu 420 | - | expression tag |
| Leu 421 | - | expression tag |
| Phe 422 | - | expression tag |
| Pro 423 | - | expression tag |
| Leu 424 | - | expression tag |
| Ile 425 | - | expression tag |
| Phe 426 | - | expression tag |
| Met 427 | - | expression tag |
| Leu 428 | - | expression tag |
| Ala 429 | - | expression tag |
| Asn 430 | - | expression tag |
| Val 431 | - | expression tag |
| Phe 432 | - | expression tag |
| Tyr 433 | - | expression tag |
| Trp 434 | - | expression tag |
| Ala 435 | - | expression tag |
| Tyr 436 | - | expression tag |
| Tyr 437 | - | expression tag |
| Met 438 | - | expression tag |
| Tyr 439 | - | expression tag |
| Phe 440 | - | expression tag |
| Glu 441 | - | expression tag |
| Phe 442 | - | expression tag |
| Gly 443 | - | expression tag |
| Gly 444 | - | expression tag |
| Ser 445 | - | expression tag |
| Arg 446 | - | expression tag |
| Gly 447 | - | expression tag |
| Ser 448 | - | expression tag |
| Ala 449 | - | expression tag |
| Trp 450 | - | expression tag |
| Ser 451 | - | expression tag |
| His 452 | - | expression tag |
| Pro 453 | - | expression tag |
| Gln 454 | - | expression tag |
| Phe 455 | - | expression tag |
| Glu 456 | - | expression tag |
| Lys 457 | - | expression tag |
| Gly 458 | - | expression tag |
| Gly 459 | - | expression tag |
| Gly 460 | - | expression tag |
| Ser 461 | - | expression tag |
| Gly 462 | - | expression tag |
| Gly 463 | - | expression tag |
| Gly 464 | - | expression tag |
| Ser 465 | - | expression tag |
| Gly 466 | - | expression tag |
| Gly 467 | - | expression tag |
| Ser 468 | - | expression tag |
| Ala 469 | - | expression tag |
| Trp 470 | - | expression tag |
| Ser 471 | - | expression tag |
| His 472 | - | expression tag |
| Pro 473 | - | expression tag |
| Gln 474 | - | expression tag |
| Phe 475 | - | expression tag |
| Glu 476 | - | expression tag |
| Lys 477 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 216425.5 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 3743.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1621.6 | |
| All* | Total formula weight | 221790.6 |
