8VSJ
Engineered peptide-specific binder in complex with HLA-DR1/CLIP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 184 | 21400.2 | 1 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DRA |
| 2 | B (B) | HLA class II histocompatibility antigen DR beta chain | polymer | 192 | 22324.9 | 1 | UniProt (D7RIG0) Pfam (PF00969) Pfam (PF07654) | Homo sapiens (human) | HLA-DRB1 protein,MHC class II antigen |
| 3 | C (C) | Superantigen | polymer | 129 | 15544.8 | 1 | UniProt (Q48898) Pfam (PF09245) | Metamycoplasma arthritidis | |
| 4 | D (H) | c44H10 Fab heavy chain | polymer | 223 | 23668.6 | 1 | Homo sapiens | ||
| 5 | E (L) | c44H10 Fab light chain | polymer | 214 | 23505.1 | 1 | Homo sapiens | ||
| 6 | F (P) | Class-II-associated invariant chain peptide | polymer | 15 | 1676.1 | 1 | UniProt (P04233) | Homo sapiens (human) | CLIP |
| 7 | G, H, I (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
A: -1 - 180 (UniProt: P01903)
B: 180 - 369 (UniProt: D7RIG0)
C: 1 - 120 (UniProt: Q48898)
| PDB | External Database | Details |
|---|---|---|
| Ser 181 | - | expression tag |
| Arg 182 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 370 | - | expression tag |
| Arg 371 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Cys 5 | Val 30 | engineered mutation |
| Ser 12 | Gln 37 | engineered mutation |
| Ile 13 | Lys 38 | engineered mutation |
| Tyr 14 | His 39 | engineered mutation |
| Leu 15 | Phe 40 | engineered mutation |
| Ala 16 | Val 41 | engineered mutation |
| Asp 34 | Asn 59 | engineered mutation |
| Lys 47 | Leu 72 | engineered mutation |
| Glu 50 | Leu 75 | engineered mutation |
| Asp 61 | Gly 86 | engineered mutation |
| Ile 63 | Val 88 | engineered mutation |
| Lys 65 | Asp 90 | engineered mutation |
| Gly 67 | Asn 92 | engineered mutation |
| Asp 68 | Gly 93 | engineered mutation |
| - | Leu 94 | deletion |
| - | Leu 95 | deletion |
| - | Glu 96 | deletion |
| - | Tyr 97 | deletion |
| Val 71 | Ile 100 | engineered mutation |
| Ile 85 | Thr 114 | engineered mutation |
| Thr 102 | Ile 131 | engineered mutation |
| Cys 115 | Ser 144 | engineered mutation |
| Trp 121 | - | expression tag |
| Leu 122 | - | expression tag |
| Glu 123 | - | expression tag |
| His 124 | - | expression tag |
| His 125 | - | expression tag |
| His 126 | - | expression tag |
| His 127 | - | expression tag |
| His 128 | - | expression tag |
| His 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 108119.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 108783.4 |
