8VQY
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus methaqualone
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Gamma-aminobutyric acid receptor subunit beta-2 | polymer | 364 | 41810.1 | 2 | UniProt (P47870) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | GABA(A) receptor subunit beta-2 |
2 | B, D | Gamma-aminobutyric acid receptor subunit alpha-1 | polymer | 358 | 41061.2 | 2 | UniProt (P14867) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | GABA(A) receptor subunit alpha-1 |
3 | E | Gamma-aminobutyric acid receptor subunit gamma-2 | polymer | 417 | 47673.1 | 1 | UniProt (P18507) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | GABA(A) receptor subunit gamma-2 |
4 | I, L | Kappa FAB light chain | polymer | 213 | 23505.9 | 2 | Mus musculus (house mouse) | ||
5 | J, K | IGG2B FAB heavy chain | polymer | 454 | 49811.0 | 2 | Mus musculus (house mouse) | ||
6 | F, G, O | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
7 | H, N, P | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
8 | M | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G40702WU) | |||
9 | A, C | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 2 | Chemie (ABU) | |||
10 | E, A, C | 2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one | non-polymer | 250.3 | 3 | Chemie (A1ADG) | |||
11 | A, B, C, D | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 4 | Chemie (PTY) | |||
12 | C, D | O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-D-serine | non-polymer | 764.0 | 2 | Chemie (Q3G) |
Sequence modifications
A, C: 1 - 307 (UniProt: P47870)
A, C: 316 - 364 (PDB: 8VQY)
B, D: 1 - 312 (UniProt: P14867)
B, D: 320 - 358 (PDB: 8VQY)
E: 1 - 322 (UniProt: P18507)
E: 330 - 380 (PDB: 8VQY)
PDB | External Database | Details |
---|---|---|
Ser 308 | - | linker |
Gln 309 | - | linker |
Pro 310 | - | linker |
Ala 311 | - | linker |
Arg 312 | - | linker |
Ala 313 | - | linker |
Ala 314 | - | linker |
Ala 315 | - | linker |
B, D: 1 - 312 (UniProt: P14867)
PDB | External Database | Details |
---|---|---|
Ser 313 | - | linker |
Gln 314 | - | linker |
Pro 315 | - | linker |
Ala 316 | - | linker |
Arg 317 | - | linker |
Ala 318 | - | linker |
Ala 319 | - | linker |
E: 1 - 322 (UniProt: P18507)
PDB | External Database | Details |
---|---|---|
Trp -36 | - | expression tag |
Ser -35 | - | expression tag |
His -34 | - | expression tag |
Pro -33 | - | expression tag |
Gln -32 | - | expression tag |
Phe -31 | - | expression tag |
Glu -30 | - | expression tag |
Lys -29 | - | expression tag |
Gly -28 | - | expression tag |
Gly -27 | - | expression tag |
Gly -26 | - | expression tag |
Ser -25 | - | expression tag |
Gly -24 | - | expression tag |
Gly -23 | - | expression tag |
Gly -22 | - | expression tag |
Ser -21 | - | expression tag |
Gly -20 | - | expression tag |
Gly -19 | - | expression tag |
Ser -18 | - | expression tag |
Ser -17 | - | expression tag |
Ala -16 | - | expression tag |
Trp -15 | - | expression tag |
Ser -14 | - | expression tag |
His -13 | - | expression tag |
Pro -12 | - | expression tag |
Gln -11 | - | expression tag |
Phe -10 | - | expression tag |
Glu -9 | - | expression tag |
Lys -8 | - | expression tag |
Leu -7 | - | expression tag |
Glu -6 | - | expression tag |
Val -5 | - | expression tag |
Leu -4 | - | expression tag |
Phe -3 | - | expression tag |
Gln -2 | - | expression tag |
Gly -1 | - | expression tag |
Pro 0 | - | expression tag |
Ser 323 | - | linker |
Gln 324 | - | linker |
Pro 325 | - | linker |
Ala 326 | - | linker |
Arg 327 | - | linker |
Ala 328 | - | linker |
Ala 329 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 9 |
Total formula weight | 360049.7 | |
Branched | Number of molecules | 7 |
Total formula weight | 5727.2 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 5421.3 | |
All* | Total formula weight | 371198.2 |