8VQY

Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus methaqualone

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Gamma-aminobutyric acid receptor subunit beta-2	polymer	364	41810.1	2	UniProt (P47870) Pfam (PF02931) Pfam (PF02932)	Homo sapiens (human)	GABA(A) receptor subunit beta-2
2	B, D (B, D)	Gamma-aminobutyric acid receptor subunit alpha-1	polymer	358	41061.2	2	UniProt (P14867) Pfam (PF02931) Pfam (PF02932)	Homo sapiens (human)	GABA(A) receptor subunit alpha-1
3	E (E)	Gamma-aminobutyric acid receptor subunit gamma-2	polymer	417	47673.1	1	UniProt (P18507) Pfam (PF02931) Pfam (PF02932)	Homo sapiens (human)	GABA(A) receptor subunit gamma-2
4	F, H (I, L)	Kappa FAB light chain	polymer	213	23505.9	2		Mus musculus (house mouse)
5	G, I (J, K)	IGG2B FAB heavy chain	polymer	454	49811.0	2		Mus musculus (house mouse)
6	J, K, O (F, G, O)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
7	L, N, P (H, N, P)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	3	In PDB GlyTouCan (G22768VO)
8	M (M)	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1721.5	1	In PDB GlyTouCan (G40702WU)
9	Q, U (A, C)	GAMMA-AMINO-BUTANOIC ACID	non-polymer		103.1	2	Chemie (ABU)
10	AA, R, V (E, A, C)	2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one	non-polymer		250.3	3	Chemie (A1ADG)
11	S, T, W, Z (A, B, C, D)	PHOSPHATIDYLETHANOLAMINE	non-polymer		734.0	4	Chemie (PTY)
12	X, Y (C, D)	O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-D-serine	non-polymer		764.0	2	Chemie (Q3G)

Sequence modifications

A, C: 1 - 307 (UniProt: P47870)

PDB	External Database	Details
Ser 308	-	linker
Gln 309	-	linker
Pro 310	-	linker
Ala 311	-	linker
Arg 312	-	linker
Ala 313	-	linker
Ala 314	-	linker
Ala 315	-	linker

A, C: 316 - 364 (PDB: 8VQY)
B, D: 1 - 312 (UniProt: P14867)

PDB	External Database	Details
Ser 313	-	linker
Gln 314	-	linker
Pro 315	-	linker
Ala 316	-	linker
Arg 317	-	linker
Ala 318	-	linker
Ala 319	-	linker

B, D: 320 - 358 (PDB: 8VQY)
E: 1 - 322 (UniProt: P18507)

PDB	External Database	Details
Trp -36	-	expression tag
Ser -35	-	expression tag
His -34	-	expression tag
Pro -33	-	expression tag
Gln -32	-	expression tag
Phe -31	-	expression tag
Glu -30	-	expression tag
Lys -29	-	expression tag
Gly -28	-	expression tag
Gly -27	-	expression tag
Gly -26	-	expression tag
Ser -25	-	expression tag
Gly -24	-	expression tag
Gly -23	-	expression tag
Gly -22	-	expression tag
Ser -21	-	expression tag
Gly -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
Ala -16	-	expression tag
Trp -15	-	expression tag
Ser -14	-	expression tag
His -13	-	expression tag
Pro -12	-	expression tag
Gln -11	-	expression tag
Phe -10	-	expression tag
Glu -9	-	expression tag
Lys -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag
Ser 323	-	linker
Gln 324	-	linker
Pro 325	-	linker
Ala 326	-	linker
Arg 327	-	linker
Ala 328	-	linker
Ala 329	-	linker

E: 330 - 380 (PDB: 8VQY)

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	360049.7
Branched	Number of molecules	7
	Total formula weight	5727.2
Non-Polymers*	Number of molecules	11
	Total formula weight	5421.3
All*	Total formula weight	371198.2

*Water molecules are not included.