8VPQ
The structure of LSD1-CoREST-HDAC1 in complex with KBTBD4IPR310delinsTTYML
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Isoform 2 of Kelch repeat and BTB domain-containing protein 4 | polymer | 536 | 60214.0 | 2 | UniProt (Q9NVX7) Pfam (PF00651) Pfam (PF07707) Pfam (PF07646) | Homo sapiens (human) | BTB and kelch domain-containing protein 4 |
| 2 | C (C) | Histone deacetylase 1 | polymer | 482 | 55178.9 | 1 | UniProt (Q13547) Pfam (PF00850) | Homo sapiens (human) | HD1,Protein deacetylase HDAC1,Protein decrotonylase HDAC1 |
| 3 | D (D) | REST corepressor 1 | polymer | 485 | 53401.4 | 1 | UniProt (Q9UKL0) Pfam (PF01448) Pfam (PF00249) Pfam (PF20878) | Homo sapiens (human) | Protein CoREST |
| 4 | E (C) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | F (D) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) |
Sequence modifications
A, B: 1 - 536 (UniProt: Q9NVX7)
| PDB | External Database | Details |
|---|---|---|
| Thr 310 | Ile 310 | conflict |
| Thr 311 | Pro 311 | conflict |
| Tyr 312 | Arg 312 | conflict |
| Met 313 | - | insertion |
| Leu 314 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 229008.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 725.4 | |
| All* | Total formula weight | 229733.7 |
