8VNV
PRC2_AJ1-450 bound to H3K36me3 with histone H3 tail engaged
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polycomb protein SUZ12 | polymer | 619 | 72265.4 | 1 | UniProt (Q15022) Pfam (PF09733) | Homo sapiens (human) | Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog |
| 2 | B (L) | EED | polymer | 441 | 50267.7 | 1 | UniProt (O75530) Pfam (PF00400) | Homo sapiens (human) | hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 3 | C (N) | RBAP48 | polymer | 425 | 47709.5 | 1 | UniProt (Q09028) Pfam (PF12265) Pfam (PF00400) | Homo sapiens (human) | Chromatin assembly factor 1 subunit C,CAF-1 subunit C,Chromatin assembly factor I p48 subunit,CAF-I 48 kDa subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48,Retinoblastoma-binding protein 4,RBBP-4,Retinoblastoma-binding protein p48 |
| 4 | D (C) | Isoform 2 of Histone-lysine N-methyltransferase EZH2 | polymer | 746 | 85492.3 | 1 | UniProt (Q15910) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) | Homo sapiens (human) | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
| 5 | E (B) | Protein Jumonji | polymer | 449 | 49174.9 | 1 | UniProt (Q92833) | Homo sapiens (human) | Jumonji/ARID domain-containing protein 2 |
| 6 | F (P) | Zinc finger protein AEBP2 | polymer | 279 | 31286.9 | 1 | UniProt (Q6ZN18) | Homo sapiens (human) | Adipocyte enhancer-binding protein 2,AE-binding protein 2 |
| 7 | G (H) | DNA (26-mer) | polymer | 23 | 7043.5 | 1 | Homo sapiens | ||
| 8 | H (I) | H3K36me3-modified histone H3 | polymer | 22 | 2322.8 | 1 | UniProt (P68431) | Homo sapiens (human) | Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l |
| 9 | I (D) | DNA (26-MER) | polymer | 26 | 8046.2 | 1 | Homo sapiens | ||
| 10 | J (C) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) |
Sequence modifications
A: 68 - 685 (UniProt: Q15022)
C: 2 - 746 (UniProt: Q15910)
| PDB | External Database | Details |
|---|---|---|
| Met 67 | - | initiating methionine |
| Asn 409 | Asp 409 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| - | Arg 298 | deletion |
| - | Lys 299 | deletion |
| - | Cys 300 | deletion |
| - | Asn 301 | deletion |
| - | Tyr 302 | deletion |
| Pro 298 | Ser 303 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 353609.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 384.4 | |
| All* | Total formula weight | 353993.5 |
