8VNV
PRC2_AJ1-450 bound to H3K36me3 with histone H3 tail engaged
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polycomb protein SUZ12 | polymer | 619 | 72265.4 | 1 | UniProt (Q15022) Pfam (PF23320) Pfam (PF09733) | Homo sapiens (human) | Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog |
| 2 | B (L) | EED | polymer | 441 | 50267.7 | 1 | UniProt (O75530) Pfam (PF00400) | Homo sapiens (human) | hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 3 | C (N) | RBAP48 | polymer | 425 | 47709.5 | 1 | UniProt (Q09028) Pfam (PF12265) Pfam (PF00400) | Homo sapiens (human) | Chromatin assembly factor 1 subunit C,CAF-1 subunit C,Chromatin assembly factor I p48 subunit,CAF-I 48 kDa subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48,Retinoblastoma-binding protein 4,RBBP-4,Retinoblastoma-binding protein p48 |
| 4 | D (C) | Isoform 2 of Histone-lysine N-methyltransferase EZH2 | polymer | 746 | 85492.3 | 1 | UniProt (Q15910) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) | Homo sapiens (human) | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
| 5 | E (B) | Protein Jumonji | polymer | 449 | 49174.9 | 1 | UniProt (Q92833) | Homo sapiens (human) | Jumonji/ARID domain-containing protein 2 |
| 6 | F (P) | Zinc finger protein AEBP2 | polymer | 279 | 31286.9 | 1 | UniProt (Q6ZN18) Pfam (PF26014) | Homo sapiens (human) | Adipocyte enhancer-binding protein 2,AE-binding protein 2 |
| 7 | G (H) | DNA (26-mer) | polymer | 23 | 7043.5 | 1 | Homo sapiens | ||
| 8 | H (I) | H3K36me3-modified histone H3 | polymer | 22 | 2322.8 | 1 | UniProt (P68431) | Homo sapiens (human) | Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l |
| 9 | I (D) | DNA (26-MER) | polymer | 26 | 8046.2 | 1 | Homo sapiens | ||
| 10 | J (C) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (25210495) PubChem (13792) PubChem (177678424) PubChem (44361184) PubChem (21125603) PubChem (46936206) PubChem (50989525) PubChem (25203782) PubChem (51380914) PubChem (52224398) PubChem (189149) PubChem (57544532) PubChem (439155) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (52224400) PubChem (5284331) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (71170554) PubChem (13231890) PubChem (164157219) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) |
Sequence modifications
A: 68 - 685 (UniProt: Q15022)
C: 2 - 746 (UniProt: Q15910)
| PDB | External Database | Details |
|---|---|---|
| Met 67 | - | initiating methionine |
| Asn 409 | Asp 409 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| - | Arg 298 | deletion |
| - | Lys 299 | deletion |
| - | Cys 300 | deletion |
| - | Asn 301 | deletion |
| - | Tyr 302 | deletion |
| Pro 298 | Ser 303 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 353609.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 384.4 | |
| All* | Total formula weight | 353993.5 |
