8VMG

Crystal structure of GSK-3 26-383 bound to Axin 383-435

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glycogen synthase kinase-3 beta	polymer	364	41538.7	2	UniProt (Q9WV60) Pfam (PF00069)	Mus musculus (house mouse)	GSK-3 beta,Serine/threonine-protein kinase GSK3B
2	C, D (C, D)	Axin-1	polymer	60	6657.3	2	UniProt (O15169)	Homo sapiens (human)	Axis inhibition protein 1,hAxin
3	E (A)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
4	AA, AB, BA, BB, CB... (A, B, C)	1,2-ETHANEDIOL	non-polymer		62.1	39	Chemie (EDO)
5	EA, FA, GA, K, L... (A)	NITRATE ION	non-polymer		62.0	8	Chemie (NO3)
6	CA, N, R, W (A)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
7	AC, HA, IA, JA, KA... (C, A, B)	SULFATE ION	non-polymer		96.1	9	Chemie (SO4)
8	NA (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
9	BC, CC, DC, OA, PA... (C, D, A, B)	CHLORIDE ION	non-polymer		35.5	15	Chemie (CL)
10	TA (B)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
11	EC, FC, GC, HC (A, B, C, D)	water	water		18.0	158	Chemie (HOH)

Sequence modifications

A, B: 26 - 383 (UniProt: Q9WV60)

PDB	External Database	Details
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag

C, D: 383 - 435 (UniProt: O15169)

PDB	External Database	Details
Gly 376	-	expression tag
Gly 377	-	expression tag
Trp 378	-	expression tag
Gly 379	-	expression tag
Ser 380	-	expression tag
Gly 381	-	expression tag
Gly 382	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	96392.0
Non-Polymers*	Number of molecules	78
	Total formula weight	5328.2
All*	Total formula weight	101720.1

*Water molecules are not included.