8VMC
Composite structure of human FASN with NADPH in State 6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fatty acid synthase | polymer | 2553 | 278722.2 | 2 | UniProt (P49327) Pfam (PF00109) Pfam (PF00550) Pfam (PF00975) Pfam (PF02801) Pfam (PF16197) Pfam (PF00698) Pfam (PF21089) Pfam (PF08242) Pfam (PF21149) Pfam (PF00107) Pfam (PF08659) | Homo sapiens (human) | Type I fatty acid synthase |
| 2 | C, D, E, F (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) |
Sequence modifications
A, B: 2 - 2511 (UniProt: P49327)
| PDB | External Database | Details |
|---|---|---|
| Met -31 | - | expression tag |
| Ser -30 | - | expression tag |
| Tyr -29 | - | expression tag |
| Tyr -28 | - | expression tag |
| Asp -27 | - | expression tag |
| Tyr -26 | - | expression tag |
| Lys -25 | - | expression tag |
| Asp -24 | - | expression tag |
| Asp -23 | - | expression tag |
| Asp -22 | - | expression tag |
| Asp -21 | - | expression tag |
| Lys -20 | - | expression tag |
| Asp -19 | - | expression tag |
| Tyr -18 | - | expression tag |
| Asp -17 | - | expression tag |
| Ile -16 | - | expression tag |
| Pro -15 | - | expression tag |
| Thr -14 | - | expression tag |
| Thr -13 | - | expression tag |
| Glu -12 | - | expression tag |
| Asn -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Tyr -9 | - | expression tag |
| Phe -8 | - | expression tag |
| Gln -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Ala -5 | - | expression tag |
| Met -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ile 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Thr 1151 | Lys 1151 | conflict |
| Leu 2512 | - | expression tag |
| Glu 2513 | - | expression tag |
| His 2514 | - | expression tag |
| His 2515 | - | expression tag |
| His 2516 | - | expression tag |
| His 2517 | - | expression tag |
| His 2518 | - | expression tag |
| His 2519 | - | expression tag |
| His 2520 | - | expression tag |
| His 2521 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 557444.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2981.7 | |
| All* | Total formula weight | 560426.1 |
