8VIS

Human TMPRSS11D complexed with a disulfide-linked autoinhibitory DDDDK peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	Transmembrane protease serine 11D non-catalytic chain	polymer	145	16330.1	4	UniProt (O60235) Pfam (PF01390)	Homo sapiens (human)
2	B, D, F, H (B, D, F, H)	Transmembrane protease serine 11D catalytic chain	polymer	244	26944.2	4	UniProt (O60235) Pfam (PF00089)	Homo sapiens (human)
3	I, O, Q (A, E, H)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
4	J, L (B, D)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	K, S (B, H)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
6	M, N, P, R, T (D, F, H)	UNKNOWN ATOM OR ION	non-polymer			5	Chemie (UNX)
7	AA, BA, U, V, W... (G, H, A, B, C...)	water	water		18.0	1149	Chemie (HOH)

Sequence modifications

A, C, E, G: 44 - 186 (UniProt: O60235)

PDB	External Database	Details
Ala 42	-	expression tag
Ala 43	-	expression tag
Asp 182	Leu 182	engineered mutation
Asp 183	Ser 183	engineered mutation
Asp 184	Glu 184	engineered mutation
Asp 185	Gln 185	engineered mutation
Lys 186	Arg 186	engineered mutation

B, D, F, H: 187 - 418 (UniProt: O60235)

PDB	External Database	Details
Glu 419	-	expression tag
Phe 420	-	expression tag
Val 421	-	expression tag
Glu 422	-	expression tag
His 423	-	expression tag
His 424	-	expression tag
His 425	-	expression tag
His 426	-	expression tag
His 427	-	expression tag
His 428	-	expression tag
His 429	-	expression tag
His 430	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	173097.2
Non-Polymers*	Number of molecules	12
	Total formula weight	381.2
All*	Total formula weight	173478.4

*Water molecules are not included.