8VHG
Structure of the BMAL1/HIF2A heterodimer in Complex with DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Endothelial PAS domain-containing protein 1 | polymer | 380 | 43372.3 | 1 | UniProt (P97481) Pfam (PF23171) Pfam (PF00989) Pfam (PF14598) | Mus musculus (house mouse) | EPAS-1,HIF-1-alpha-like factor,HLF,mHLF,HIF-related factor,HRF,Hypoxia-inducible factor 2-alpha,HIF-2-alpha,HIF2-alpha |
| 2 | B (B) | Basic helix-loop-helix ARNT-like protein 1 | polymer | 436 | 49248.1 | 1 | UniProt (Q9WTL8) Pfam (PF00010) Pfam (PF00989) Pfam (PF14598) | Mus musculus (house mouse) | Arnt3,Aryl hydrocarbon receptor nuclear translocator-like protein 1,Brain and muscle ARNT-like 1 |
| 3 | C (C) | Reverse strand DNA containing HRE motif | polymer | 24 | 7245.7 | 1 | Mus musculus | ||
| 4 | D (D) | Forward strand DNA containing HRE motif | polymer | 24 | 7498.8 | 1 | Mus musculus |
Sequence modifications
A: 3 - 361 (UniProt: P97481)
B: 68 - 488 (UniProt: Q9WTL8)
| PDB | External Database | Details |
|---|---|---|
| Met -18 | - | expression tag |
| Gly -17 | - | expression tag |
| Ser -16 | - | expression tag |
| Ser -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Val -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| His 1 | - | expression tag |
| Met 2 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 274 | - | insertion |
| Glu 489 | - | expression tag |
| Asn 490 | - | expression tag |
| Leu 491 | - | expression tag |
| Tyr 492 | - | expression tag |
| Phe 493 | - | expression tag |
| Gln 494 | - | expression tag |
| Ser 495 | - | expression tag |
| Asp 496 | - | expression tag |
| Tyr 497 | - | expression tag |
| Lys 498 | - | expression tag |
| Asp 499 | - | expression tag |
| Asp 500 | - | expression tag |
| Asp 501 | - | expression tag |
| Asp 502 | - | expression tag |
| Lys 503 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 107364.9 | |
| All* | Total formula weight | 107364.9 |
