8VH4
Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 monomer state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Leucine-rich repeat serine/threonine-protein kinase 2 | polymer | 2527 | 286427.7 | 1 | UniProt (Q5S007) Pfam (PF23744) Pfam (PF23745) Pfam (PF13855) Pfam (PF08477) Pfam (PF16095) Pfam (PF25497) Pfam (PF00069) Pfam (PF23748) | Homo sapiens (human) | Dardarin |
| 2 | B (B) | Ras-related protein Rab-12 | polymer | 176 | 20207.4 | 1 | UniProt (Q6IQ22) Pfam (PF00071) | Homo sapiens (human) | |
| 3 | C (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 4 | D (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 5 | E (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 6 | F (B) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) |
Sequence modifications
A: 1 - 2527 (UniProt: Q5S007)
B: 36 - 211 (UniProt: Q6IQ22)
| PDB | External Database | Details |
|---|---|---|
| His 50 | Arg 50 | conflict |
| Thr 1647 | Ser 1647 | conflict |
| Thr 2397 | Met 2397 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Leu 101 | Gln 101 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 306635.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1495.9 | |
| All* | Total formula weight | 308130.9 |
