8VH1

CH235.12 Fab bound to the HIV-1 CH505.M5 SOSIP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, I (A, E, I)	CH505.M5 SOSIP gp120	polymer	464	52025.3	3	UniProt (M4M0W3)	Human immunodeficiency virus 1	Env polyprotein
2	B, F, J (B, F, J)	CH505.M5 SOSIP gp41	polymer	158	17932.5	3	UniProt (M4M0W3) UniProt (by SIFTS) (D0PUM0)	Human immunodeficiency virus 1	Env polyprotein
3	C, G, K (C, G, K)	CH235.I60 Fab Heavy Chain	polymer	220	23684.5	3		Homo sapiens (human)
4	D, H, L (D, H, L)	CH235.I60 Fab Light Chain	polymer	211	23113.6	3		Homo sapiens (human)

Sequence modifications

A, E, I: 34 - 504 (UniProt: M4M0W3)

PDB	External Database	Details
Ala 31	-	expression tag
Glu 32	-	expression tag
Asn 33	-	expression tag
Leu 34	Met 30	conflict
Lys 64	Glu 60	conflict
Lys 488	Glu 473	conflict
Ile 489	Val 474	conflict
Glu 490	Lys 475	conflict
Arg 498	Asn 483	conflict
Cys 499	Ala 484	conflict
Lys 500	Arg 485	conflict
Gly 505	-	expression tag

B, F, J: 507 - 664 (UniProt: M4M0W3)

PDB	External Database	Details
Arg 507	Glu 490	conflict
Arg 509	Glu 492	conflict
Arg 510	Lys 493	conflict
Ile 515	Met 498	conflict
Met 535	Ile 518	conflict
Asn 543	Gln 526	conflict
Arg 557	Lys 540	conflict
Pro 559	Ile 542	conflict
Leu 565	Met 548	conflict
Val 583	Leu 566	conflict
Arg 588	Lys 571	conflict
Ile 595	Met 578	conflict
Cys 605	Thr 588	conflict
Pro 609	Tyr 592	conflict
Arg 617	Lys 600	conflict
Asn 618	Thr 601	conflict
Leu 619	Tyr 602	conflict
Ser 620	Gly 603	conflict
Glu 621	Asp 604	conflict
Leu 629	Met 612	conflict
Asp 632	Glu 615	conflict
Lys 633	Arg 616	conflict
Gln 640	Glu 623	conflict
Gly 644	Glu 627	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	350267.8
All*	Total formula weight	350267.8

*Water molecules are not included.