8VGY
Crystal structure of human apoptosis-inducing factor (AIF) bound to the fused N-terminal domain of CHCHD4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Apoptosis-inducing factor 1, mitochondrial,Mitochondrial intermembrane space import and assembly protein 40 | polymer | 571 | 62269.5 | 2 | UniProt (O95831) UniProt (Q8N4Q1) Pfam (PF00070) Pfam (PF14721) | Homo sapiens (human) | |
| 2 | C, F (A, C) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
| 3 | D, E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | G, H (A, C) | water | water | 18.0 | 388 | Chemie (HOH) |
Sequence modifications
A, C: 104 - 613 (UniProt: O95831)
A, C: 1001 - 1045 (UniProt: Q8N4Q1)
| PDB | External Database | Details |
|---|---|---|
| Met 103 | - | initiating methionine |
| Ala 196 | Trp 196 | engineered mutation |
| Ser 992 | - | linker |
| Gly 993 | - | linker |
| Ser 994 | - | linker |
| Gly 995 | - | linker |
| Pro 996 | - | linker |
| Gly 997 | - | linker |
| Ser 998 | - | linker |
| Gly 999 | - | linker |
| Ser 1000 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Leu 1046 | - | expression tag |
| Glu 1047 | - | expression tag |
| Val 1048 | - | expression tag |
| Leu 1049 | - | expression tag |
| Phe 1050 | - | expression tag |
| Gln 1051 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 124538.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1695.2 | |
| All* | Total formula weight | 126234.1 |
