8VGW

VRC01 Fab bound to the HIV-1 CH848 DE3 SOSIP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, I (A, E, I)	CH848 DE3 SOSIP gp120	polymer	471	52847.9	3	UniProt (A0A1W6IPB2) Pfam (PF00516)	Human immunodeficiency virus 1	Env polyprotein
2	B, F, J (B, F, J)	CH848 DE3 SOSIP gp41	polymer	153	17180.6	3	UniProt (A0A1W6IPB2) Pfam (PF00517) UniProt (by SIFTS) (D0PUM0)	Human immunodeficiency virus 1	Env polyprotein
3	C, G, K (C, G, K)	VRC01 Fab Heavy Chain	polymer	121	13801.7	3		Homo sapiens (human)
4	D, H, L (D, H, L)	VRC01 Fab Light Chain	polymer	101	11100.2	3		Homo sapiens (human)

Sequence modifications

A, E, I: 4 - 469 (UniProt: A0A1W6IPB2)

PDB	External Database	Details
Ala 1	-	expression tag
Glu 2	-	expression tag
Asn 3	-	expression tag
Cys 163	Val 189	conflict
Cys 391	Ala 417	conflict
Lys 448	Glu 474	conflict
Glu 450	Gln 476	conflict
Val 454	Ile 480	conflict
Arg 458	Gly 484	conflict
Cys 459	Ala 485	conflict
Gly 465	Glu 491	conflict
Arg 467	Glu 493	conflict
Arg 468	Lys 494	conflict
Arg 470	-	expression tag
Arg 471	-	expression tag

B, F, J: 472 - 624 (UniProt: A0A1W6IPB2)

PDB	External Database	Details
Val 473	Ala 497	conflict
Ile 475	Leu 499	conflict
Val 478	Leu 502	conflict
Met 495	Ile 519	conflict
Asn 503	Gln 527	conflict
Lys 527	Gln 551	conflict
Val 543	Leu 567	conflict
Arg 548	Lys 572	conflict
Ile 555	Met 579	conflict
Cys 565	Thr 589	conflict
Ser 572	Thr 596	conflict
Arg 577	Lys 601	conflict
Asn 578	Ser 602	conflict
Leu 579	Glu 603	conflict
Ser 580	Thr 604	conflict
Glu 581	Asp 605	conflict
Leu 589	Met 613	conflict
Asp 592	Glu 616	conflict
Lys 593	Arg 617	conflict
Gln 600	Glu 624	conflict
Ile 601	Thr 625	conflict
Gly 604	Lys 628	conflict
Glu 608	Asp 632	conflict
Lys 615	Arg 639	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	284791.1
All*	Total formula weight	284791.1

*Water molecules are not included.