8VGV
DH270.6 Fab bound to the HIV-1 CH848 DE3 SOSIP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, I (A, E, I) | CH848 DE3 SOSIP gp120 | polymer | 462 | 51665.5 | 3 | UniProt (A0A1W6IPB2) | Human immunodeficiency virus 1 | Env polyprotein |
| 2 | B, F, J (B, F, J) | CH848 DE3 SOSIP gp41 | polymer | 153 | 17179.5 | 3 | UniProt (A0A1W6IPB2) | Human immunodeficiency virus 1 | Env polyprotein |
| 3 | C, G, K (C, G, K) | DH270.6 Antibody Fab Heavy Chain | polymer | 126 | 14169.7 | 3 | Homo sapiens (human) | ||
| 4 | D, H, L (D, H, L) | DH270.6 Antibody Fab Light Chain | polymer | 108 | 11295.6 | 3 | Homo sapiens (human) | ||
| 5 | M, O, Q (M, O, Q) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 3 | In PDB GlyTouCan (G01760ZU) | |||
| 6 | N, P, R (N, P, R) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) |
Sequence modifications
A, E, I: 34 - 505 (UniProt: A0A1W6IPB2)
B, F, J: 512 - 664 (UniProt: A0A1W6IPB2)
| PDB | External Database | Details |
|---|---|---|
| Glu 32 | - | expression tag |
| Asn 33 | - | expression tag |
| Asp 133 | Asn 129 | conflict |
| Thr 138 | Asn 134 | conflict |
| Cys 201 | Val 189 | conflict |
| Cys 433 | Ala 417 | conflict |
| Lys 490 | Glu 474 | conflict |
| Glu 492 | Gln 476 | conflict |
| Val 496 | Ile 480 | conflict |
| Arg 500 | Gly 484 | conflict |
| Cys 501 | Ala 485 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Val 513 | Ala 497 | conflict |
| Ile 515 | Leu 499 | conflict |
| Val 518 | Leu 502 | conflict |
| Met 535 | Ile 519 | conflict |
| Asn 543 | Gln 527 | conflict |
| Val 583 | Leu 567 | conflict |
| Arg 588 | Lys 572 | conflict |
| Ile 595 | Met 579 | conflict |
| Cys 605 | Thr 589 | conflict |
| Ser 612 | Thr 596 | conflict |
| Arg 617 | Lys 601 | conflict |
| Asn 618 | Ser 602 | conflict |
| Leu 619 | Glu 603 | conflict |
| Ser 620 | Thr 604 | conflict |
| Glu 621 | Asp 605 | conflict |
| Leu 629 | Met 613 | conflict |
| Asp 632 | Glu 616 | conflict |
| Lys 633 | Arg 617 | conflict |
| Gln 640 | Glu 624 | conflict |
| Ile 641 | Thr 625 | conflict |
| Gly 644 | Lys 628 | conflict |
| Glu 648 | Asp 632 | conflict |
| Lys 655 | Arg 639 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 282930.8 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 4978.5 | |
| All* | Total formula weight | 287909.3 |
