8VGP
CryoEM structure of Angiopoietin-2 in complex with engineered conformationally rigid Fab 5A12.6DS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Angiopoietin-2 | polymer | 232 | 26530.4 | 1 | UniProt (O15123) Pfam (PF00147) | Homo sapiens (human) | ANG-2 |
| 2 | B (H) | Fab 5A12.6DS heavy chain | polymer | 236 | 25234.4 | 1 | Homo sapiens (human) | ||
| 3 | C (L) | Fab 5A12.6DS light chain | polymer | 215 | 23230.1 | 1 | Homo sapiens (human) | ||
| 4 | D (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | E, F, G (A, H, L) | water | water | 18.0 | 43 | Chemie (HOH) |
Sequence modifications
A: 277 - 496 (UniProt: O15123)
| PDB | External Database | Details |
|---|---|---|
| Ala 274 | - | expression tag |
| Gly 275 | - | expression tag |
| Ser 276 | - | expression tag |
| Gly 497 | - | expression tag |
| Asn 498 | - | expression tag |
| Ser 499 | - | expression tag |
| His 500 | - | expression tag |
| His 501 | - | expression tag |
| His 502 | - | expression tag |
| His 503 | - | expression tag |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 74994.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 40.1 | |
| All* | Total formula weight | 75034.9 |
