8VG2

Cryo-EM structure of FoxA1 and GATA4 in complex with H14 chromatosome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, E)	Histone H3.1	polymer	136	15437.2	2	UniProt (P68431) Pfam (PF00125)	Homo sapiens (human)	Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l
2	B, F (B, F)	Histone H4	polymer	103	11394.4	2	UniProt (P62805) Pfam (PF15511)	Homo sapiens (human)
3	C, G (C, G)	Histone H2A type 1-B/E	polymer	130	14165.6	2	UniProt (P04908) Pfam (PF00125) Pfam (PF16211)	Homo sapiens (human)	Histone H2A.2,Histone H2A/a,Histone H2A/m
4	D, H (D, H)	Histone H2B type 1-J	polymer	126	13935.2	2	UniProt (P06899) Pfam (PF00125)	Homo sapiens (human)	Histone H2B.1,Histone H2B.r,H2B/r
5	I (I)	DNA (196-MER)	polymer	211	64918.3	1		synthetic construct
6	J (J)	DNA (196-MER)	polymer	211	65368.7	1		synthetic construct
7	K (O)	Hepatocyte nuclear factor 3-alpha	polymer	478	50022.6	1	UniProt (P55317) Pfam (PF08430) Pfam (PF00250) Pfam (PF09354)	Homo sapiens (human)	HNF-3-alpha,HNF-3A,Forkhead box protein A1,Transcription factor 3A,TCF-3A
8	L (U)	Histone H1.4	polymer	225	22760.4	1	UniProt (P10412) Pfam (PF00538)	Homo sapiens (human)	Histone H1b,Histone H1s-4

Sequence modifications

O: 1 - 472 (UniProt: P55317)

PDB	External Database	Details
His 473	-	expression tag
His 474	-	expression tag
His 475	-	expression tag
His 476	-	expression tag
His 477	-	expression tag
His 478	-	expression tag

U: 0 - 218 (UniProt: P10412)

PDB	External Database	Details
His 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	312934.8
All*	Total formula weight	312934.8

*Water molecules are not included.