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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8VFT

Translating 80S rabbit ribosome stalled by emetine with eEF2

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		uL2polymer25728088.91UniProt (G1TT27)
Pfam (PF00181)
Pfam (PF03947)		Oryctolagus cuniculus (rabbit)
2B
(B)		uL3polymer40346108.01UniProt (G1TL06)
Pfam (PF00297)		Oryctolagus cuniculus (rabbit)
3C
(C)		uL4polymer42547727.61UniProt (G1SVW5)
Pfam (PF00573)
Pfam (PF14374)		Oryctolagus cuniculus (rabbit)
4D
(D)		uL18polymer29734481.81UniProt (G1SYJ6)
Pfam (PF17144)
Pfam (PF14204)
UniProt (by SIFTS) (P19949)		Oryctolagus cuniculus (rabbit)
5E
(E)		eL6polymer29133028.31UniProt (G1SKF7)
Pfam (PF03868)
Pfam (PF01159)		Oryctolagus cuniculus (rabbit)
6F
(F)		uL30polymer24729201.81UniProt (G1TUB1)
Pfam (PF08079)
Pfam (PF00327)
UniProt (by SIFTS) (A0AAG1W3S3)		Oryctolagus cuniculus (rabbit)
7G
(G)		eL8polymer31936221.51UniProt (G1STW0)
Pfam (PF01248)		Oryctolagus cuniculus (rabbit)
8H
(H)		uL6polymer19221871.41UniProt (G1SWI6)
Pfam (PF00347)		Oryctolagus cuniculus (rabbit)
9I
(I)		uL16polymer21424643.11UniProt (B7NZQ2)
Pfam (PF00252)		Oryctolagus cuniculus (rabbit)
10J
(J)		uL5polymer17820288.51UniProt (G1TUB8)
Pfam (PF00281)
Pfam (PF00673)		Oryctolagus cuniculus (rabbit)
11K
(L)		eL13polymer21124331.71UniProt (G1TPV0)
Pfam (PF01294)
UniProt (by SIFTS) (G1TKB3)		Oryctolagus cuniculus (rabbit)
12L
(M)		eL14polymer21823870.51UniProt (G1SZ12)
Pfam (PF01929)		Oryctolagus cuniculus (rabbit)
13M
(N)		eL15polymer20424207.31UniProt (G1T0C1)
Pfam (PF00827)		Oryctolagus cuniculus (rabbit)
14N
(O)		uL13polymer20323533.31Pfam (PF00572)
UniProt (by SIFTS) (G1TVS8)		Oryctolagus cuniculus (rabbit)
15O
(P)		uL22polymer18421444.21UniProt (G1TVT6)
Pfam (PF00237)
UniProt (by SIFTS) (G1SCJ6)		Oryctolagus cuniculus (rabbit)
16P
(Q)		eL18polymer18821699.71UniProt (G1TFE0)
Pfam (PF17135)		Oryctolagus cuniculus (rabbit)
17Q
(R)		eL19polymer19623535.31UniProt (G1TJR3)
Pfam (PF01280)
Pfam (PF25476)		Oryctolagus cuniculus (rabbit)
18R
(S)		eL20polymer17620827.61UniProt (G1TTY7)
Pfam (PF01775)		Oryctolagus cuniculus (rabbit)
19S
(T)		eL21polymer16018610.01UniProt (G1SHQ2)
Pfam (PF01157)		Oryctolagus cuniculus (rabbit)
20T
(U)		eL22polymer12814813.01UniProt (G1TSG1)
Pfam (PF01776)		Oryctolagus cuniculus (rabbit)
21U
(V)		uL14polymer14014892.51UniProt (G1T6D1)
Pfam (PF00238)		Oryctolagus cuniculus (rabbit)
22V
(W)		eL24polymer15717825.11UniProt (G1SE28)
Pfam (PF01246)		Oryctolagus cuniculus (rabbit)
23W
(X)		uL23polymer15617768.21UniProt (G1SE76)
Pfam (PF03939)
Pfam (PF00276)		Oryctolagus cuniculus (rabbit)
24X
(Y)		uL24polymer14517303.41UniProt (G1SQH0)
Pfam (PF16906)
Pfam (PF00467)		Oryctolagus cuniculus (rabbit)
25Y
(Z)		eL27polymer13615835.81UniProt (G1TXF6)
Pfam (PF00467)
Pfam (PF01777)		Oryctolagus cuniculus (rabbit)
26Z
(a)		uL15polymer14816620.61UniProt (G1SNY0)
Pfam (PF00828)		Oryctolagus cuniculus (rabbit)
27AA
(b)		eL29polymer24526708.71UniProt (G1SGR6)
Pfam (PF01779)		Oryctolagus cuniculus (rabbit)
28BA
(c)		eL30polymer11512807.11UniProt (G1TDL2)
Pfam (PF01248)		Oryctolagus cuniculus (rabbit)
29CA
(d)		eL31polymer12514494.91UniProt (G1SHG0)
Pfam (PF01198)		Oryctolagus cuniculus (rabbit)
30DA
(e)		eL32polymer13515898.91UniProt (G1U437)
Pfam (PF01655)
UniProt (by SIFTS) (G1TUN8)		Oryctolagus cuniculus (rabbit)
31EA
(f)		eL33polymer11012580.81UniProt (G1SF08)
Pfam (PF01247)		Oryctolagus cuniculus (rabbit)
32FA
(g)		eL34polymer11713326.11UniProt (G1TXG5)
Pfam (PF01199)		Oryctolagus cuniculus (rabbit)
33GA
(h)		uL29polymer12314566.61UniProt (G1SIT5)
Pfam (PF00831)		Oryctolagus cuniculus (rabbit)
34HA
(i)		eL36polymer10512263.81UniProt (G1TTQ5)
Pfam (PF01158)		Oryctolagus cuniculus (rabbit)
35IA
(j)		eL37polymer9711111.01UniProt (U3KPD5)
Pfam (PF01907)		Oryctolagus cuniculus (rabbit)
36JA
(k)		eL38polymer708238.91UniProt (G1U001)
Pfam (PF01781)		Oryctolagus cuniculus (rabbit)
37KA
(l)		eL39polymer516455.81UniProt (G1TTN1)
Pfam (PF00832)		Oryctolagus cuniculus (rabbit)
38LA
(m)		eL40polymer9310865.91UniProt (A0A2K5PSA0)
Pfam (PF00240)
Pfam (PF01020)		Oryctolagus cuniculus (rabbit)Ubiquitin-60S ribosomal protein L40
39MA
(n)		eL41polymer253473.51UniProt (A0A087WNH4)
Pfam (PF05162)		Oryctolagus cuniculus (rabbit)60s ribosomal protein l41
40NA
(o)		eL42polymer10612477.01UniProt (G1U344)
Pfam (PF00935)
UniProt (by SIFTS) (G1T040)		Oryctolagus cuniculus (rabbit)
41OA
(p)		eL43polymer9210299.41UniProt (G1SY53)
Pfam (PF01780)		Oryctolagus cuniculus (rabbit)
42PA
(r)		eL28polymer13715783.61UniProt (G1U7L1)
Pfam (PF01778)		Oryctolagus cuniculus (rabbit)
43QA
(s)		uL10polymer31834380.51UniProt (G1SPK4)
Pfam (PF00466)
Pfam (PF17777)
Pfam (PF00428)		Oryctolagus cuniculus (rabbit)
44RA
(t)		uL11polymer16517847.61UniProt (G1SMR7)
Pfam (PF03946)
Pfam (PF00298)		Oryctolagus cuniculus (rabbit)
45SA
(5)		28S rRNApolymer35431149054.11Oryctolagus cuniculus (rabbit)
46TA
(7)		5S rRNApolymer12038691.91GenBank (X06789.1)Oryctolagus cuniculus (rabbit)
47UA
(8)		5.8S rRNApolymer15650157.71Oryctolagus cuniculus (rabbit)
48VA
(v)		eEF2polymer85895605.41UniProt (P55823)
Pfam (PF00009)
Pfam (PF03144)
Pfam (PF14492)
Pfam (PF03764)
Pfam (PF00679)		Oryctolagus cuniculus (rabbit)EF-2
49WA
(9)		18S rRNApolymer1869603376.81Oryctolagus cuniculus (rabbit)
50XA
(AA)		uS2polymer29532958.01UniProt (G1TLT8)
Pfam (PF00318)
Pfam (PF16122)		Oryctolagus cuniculus (rabbit)40S ribosomal protein SA, 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40
51YA
(BB)		eS1polymer26430002.11UniProt (G1SS70)
Pfam (PF01015)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S3a
52ZA
(CC)		uS5polymer29331327.41Oryctolagus cuniculus (rabbit)
53AB
(DD)		uS3polymer24326715.31UniProt (G1TNM3)
Pfam (PF07650)
Pfam (PF00189)		Oryctolagus cuniculus (rabbit)
54BB
(EE)		eS4polymer26329654.91UniProt (G1TK17)
Pfam (PF08071)
Pfam (PF00900)
Pfam (PF00467)
Pfam (PF16121)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S4
55CB
(FF)		uS7polymer20422913.51UniProt (G1TFM5)
Pfam (PF00177)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S5
56DB
(GG)		eS6polymer24928751.91UniProt (G1TM55)
Pfam (PF01092)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S6
57EB
(HH)		eS7polymer19422168.91UniProt (G1SVB0)
Pfam (PF01251)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S7
58FB
(II)		eS8polymer20824263.41UniProt (G1TJW1)
Pfam (PF01201)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S8
59GB
(JJ)		uS4polymer19422641.61UniProt (B7NZS8)
Pfam (PF00163)
Pfam (PF01479)		Oryctolagus cuniculus (rabbit)Ribosomal protein S9
60HB
(KK)		eS10polymer16518933.81UniProt (G1TPV3)
Pfam (PF03501)		Oryctolagus cuniculus (rabbit)
61IB
(LL)		uS17polymer15818468.81UniProt (G1TRM4)
Pfam (PF16205)
Pfam (PF00366)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S11
62JB
(MM)		eS12polymer13214539.01UniProt (G1SFR8)
Pfam (PF01248)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S12
63KB
(NN)		uS15polymer15117259.41UniProt (G1SP51)
Pfam (PF08069)
Pfam (PF00312)		Oryctolagus cuniculus (rabbit)Ribosomal protein S13
64LB
(OO)		uS11polymer16818134.01UniProt (G1U472)
Pfam (PF00411)
UniProt (by SIFTS) (G1T1F0)		Oryctolagus cuniculus (rabbit)
65MB
(PP)		uS19polymer14517049.21UniProt (G1U0Q2)
Pfam (PF00203)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S15
66NB
(QQ)		uS9polymer14616477.41UniProt (G1SGX4)
Pfam (PF00380)		Oryctolagus cuniculus (rabbit)
67OB
(RR)		eS17polymer13515552.11UniProt (G1TU13)
Pfam (PF00833)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S17
68PB
(SS)		uS13polymer15217759.81UniProt (G1TPG3)
Pfam (PF00416)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S18
69QB
(TT)		eS19polymer14516106.61UniProt (G1TN62)
Pfam (PF01090)		Oryctolagus cuniculus (rabbit)
70RB
(UU)		uS10polymer11913398.81UniProt (G1SIZ2)
Pfam (PF00338)		Oryctolagus cuniculus (rabbit)
71SB
(VV)		eS21polymer839124.41UniProt (G1TM82)
Pfam (PF01249)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S21
72TB
(WW)		uS8polymer13014865.61UniProt (G1TG89)
Pfam (PF00410)		Oryctolagus cuniculus (rabbit)40S Ribosomal protein S15a
73UB
(XX)		uS12polymer14315844.71UniProt (G1SZ47)
Pfam (PF00164)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S23
74VB
(YY)		eS24polymer13015107.91UniProt (G1T3D8)
Pfam (PF01282)
UniProt (by SIFTS) (A0A5F9CBF4)		Oryctolagus cuniculus (rabbit)
75WB
(ZZ)		eS25polymer12513776.21UniProt (G1TDB3)
Pfam (PF03297)		Oryctolagus cuniculus (rabbit)
76XB
(aa)		eS26polymer11513047.51UniProt (G1TFE8)
Pfam (PF01283)		Oryctolagus cuniculus (rabbit)
77YB
(bb)		eS27polymer849480.21UniProt (G1TZ76)
Pfam (PF01667)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S27
78ZB
(cc)		eS28polymer697855.11UniProt (G1TIB4)
Pfam (PF01200)		Oryctolagus cuniculus (rabbit)40S Ribosomal protein S28
79AC
(dd)		uS14polymer566690.81UniProt (G1U7M4)
Pfam (PF00253)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S29
80BC
(ee)		eS30polymer13314498.91UniProt (G1T8A2)
Pfam (PF00240)
Pfam (PF04758)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S30
81CC
(ff)		eS31polymer15618004.01UniProt (G1SK22)
Pfam (PF00240)
Pfam (PF01599)		Oryctolagus cuniculus (rabbit)Ribosomal protein S27a
82DC
(gg)		RACK1polymer31735115.71UniProt (G1SJB4)
Pfam (PF00400)		Oryctolagus cuniculus (rabbit)
83EC
(3)		E-site tRNApolymer7524102.31Oryctolagus cuniculus (rabbit)
84FC
(w)		mRNApolymer61792.01Oryctolagus cuniculus (rabbit)
85GC
(2)		P-site tRNApolymer7624453.51Oryctolagus cuniculus (rabbit)
86AD, AE, AF, AG, AH...
(5, 9, TT, aa, w...)		MAGNESIUM IONnon-polymer24.3276Chemie (MG)
PubChem (888)
87CN, DN, EN, QC, SC...
(aa, dd, ff, g, j...)		ZINC IONnon-polymer65.48Chemie (ZN)
88TK
(v)		GUANOSINE-5'-DIPHOSPHATEnon-polymer443.21Chemie (GDP)
PubChem (136073927)
PubChem (135398619)
PubChem (135402030)
PubChem (135431654)
PubChem (135566337)
PubChem (135760556)
PubChem (136026707)
PubChem (136053418)
PubChem (136663964)
PubChem (136664748)
PubChem (136759848)
PubChem (136759849)
PubChem (136759850)
PubChem (136836636)
PubChem (136847074)
PubChem (172898537)
89YM
(9)		emetinenon-polymer480.61Chemie (34G)
Sequence modifications
C: 1 - 425 (UniProt: G1SVW5)
PDBExternal DatabaseDetails
Lys 378-insertion
Val 379-insertion
Lys 380-insertion
Lys 381-insertion
Pro 382-insertion
Arg 383-insertion
Ala 384-insertion
Val 385-insertion
Gly 386-insertion
Ile 387-insertion
Lys 388-insertion
Gln 389-insertion
F: 1 - 247 (UniProt: G1TUB1)
PDBExternal DatabaseDetails
Arg 61Gly 61conflict
Arg 93Gly 93conflict
Met 131Val 131conflict
Ile 153Val 153conflict
G: -52 - 266 (UniProt: G1STW0)
PDBExternal DatabaseDetails
Gly 191Cys 244conflict
L: 1 - 211 (UniProt: G1TPV0)
PDBExternal DatabaseDetails
Ile 46-insertion
Ala 47-insertion
Pro 48-insertion
Arg 49-insertion
Pro 50-insertion
Ala 51-insertion
Ala 52-insertion
Gly 53-insertion
Pro 54-insertion
Q: 1 - 188 (UniProt: G1TFE0)
PDBExternal DatabaseDetails
Asp 4Asn 4conflict
Arg 14Trp 14conflict
Met 53Leu 53conflict
Arg 58Trp 58conflict
Arg 75Gln 75conflict
Ala 80Pro 80conflict
Val 86Ile 86conflict
Arg 104His 104conflict
Arg 110Cys 110conflict
Val 137Gly 137conflict
Gly 157Arg 157conflict
Arg 181Trp 181conflict
R: 1 - 196 (UniProt: G1TJR3)
PDBExternal DatabaseDetails
Arg 38Cys 38conflict
Arg 64Gln 64conflict
Thr 94Lys 94conflict
S: 1 - 175 (UniProt: G1TTY7)
PDBExternal DatabaseDetails
Met 1Thr 1conflict
Pro 18-insertion
Thr 19-insertion
Pro 20Ser 18conflict
Cys 22Ser 20conflict
Arg 23Pro 21conflict
Thr 24Ala 22conflict
Ser 49Leu 47conflict
Gln 50Glu 48conflict
Arg 95His 93conflict
Thr 101Ile 99conflict
Thr 102Met 100conflict
Gly 104Ser 102conflict
Ile 126Val 124conflict
Ile 132Met 130conflict
Ser 135Ala 133conflict
Lys 136Arg 134conflict
Arg 138Pro 136conflict
Lys 149Arg 147conflict
Lys 151Arg 149conflict
Thr 168Tyr 166conflict
Thr 169Ala 167conflict
Phe 176-insertion
U: 1 - 128 (UniProt: G1TSG1)
PDBExternal DatabaseDetails
Leu 18Val 18conflict
Gly 32Arg 32conflict
Ala 36Glu 36conflict
Phe 39Ser 39conflict
Gly 54Arg 54conflict
Val 60Ala 60conflict
Ser 62Thr 62conflict
Leu 63Ile 63conflict
Arg 97His 97conflict
Thr 106Ser 106conflict
Glu 126Asp 126conflict
k: 1 - 70 (UniProt: G1U001)
PDBExternal DatabaseDetails
Lys 24Asn 24conflict
7: 1 - 120 (GenBank: X06789.1)
PDBExternal DatabaseDetails
U 2N 2conflict
C 36N 36conflict
U 102N 102conflict
U 112N 112conflict
U 114N 114conflict
U 119C 119conflict
U 120N 120conflict
v: 1 - 858 (UniProt: P55823)
PDBExternal DatabaseDetails
Gly 847-insertion
AA: 1 - 295 (UniProt: G1TLT8)
PDBExternal DatabaseDetails
Thr 114Ala 114conflict
EE: 1 - 263 (UniProt: G1TK17)
PDBExternal DatabaseDetails
Gly 25Ser 25conflict
Arg 51Lys 51conflict
Thr 78Ala 78conflict
Val 156Met 156conflict
II: 1 - 208 (UniProt: G1TJW1)
PDBExternal DatabaseDetails
Arg 47Gly 47conflict
TT: 1 - 145 (UniProt: G1TN62)
PDBExternal DatabaseDetails
Gly 119Trp 119conflict
VV: 1 - 83 (UniProt: G1TM82)
PDBExternal DatabaseDetails
Asn 3Ser 3conflict
Asp 4Asn 4conflict
Gln 33Pro 33conflict
Phe 50Ser 50conflict
Ala 75Ser 75conflict
Asp 76His 76conflict
Lys 81Gln 81conflict
aa: 1 - 115 (UniProt: G1TFE8)
PDBExternal DatabaseDetails
Arg 28Cys 28conflict
Ala 56Val 56conflict
Arg 109Pro 109conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains85
Total formula weight3508079.7
Non-Polymers*Number of molecules286
Total formula weight8155.3
All*Total formula weight3516234.9
*Water molecules are not included.

253389

PDB entries from 2026-05-13

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