8VF7

Modifying portion of human FASN with NADPH and the ACP at the ER domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Fatty acid synthase	polymer	2553	278722.2	1	UniProt (P49327) Pfam (PF00109) Pfam (PF00550) Pfam (PF00975) Pfam (PF02801) Pfam (PF16197) Pfam (PF00698) Pfam (PF21089) Pfam (PF08242) Pfam (PF21149) Pfam (PF00107) Pfam (PF08659)	Homo sapiens (human)	Type I fatty acid synthase
2	B (B)	Fatty acid synthase	polymer	2553	279062.6	1	UniProt (P49327) Pfam (PF00109) Pfam (PF02801) Pfam (PF16197) Pfam (PF00698) Pfam (PF21089) Pfam (PF08242) Pfam (PF21149) Pfam (PF00107) Pfam (PF08659) Pfam (PF00550) Pfam (PF00975)	Homo sapiens (human)	Type I fatty acid synthase
3	C, D, E, F (A, B)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	4	Chemie (NDP)

Sequence modifications

A: 2 - 2511 (UniProt: P49327)

PDB	External Database	Details
Met -31	-	initiating methionine
Ser -30	-	expression tag
Tyr -29	-	expression tag
Tyr -28	-	expression tag
Asp -27	-	expression tag
Tyr -26	-	expression tag
Lys -25	-	expression tag
Asp -24	-	expression tag
Asp -23	-	expression tag
Asp -22	-	expression tag
Asp -21	-	expression tag
Lys -20	-	expression tag
Asp -19	-	expression tag
Tyr -18	-	expression tag
Asp -17	-	expression tag
Ile -16	-	expression tag
Pro -15	-	expression tag
Thr -14	-	expression tag
Thr -13	-	expression tag
Glu -12	-	expression tag
Asn -11	-	expression tag
Leu -10	-	expression tag
Tyr -9	-	expression tag
Phe -8	-	expression tag
Gln -7	-	expression tag
Gly -6	-	expression tag
Ala -5	-	expression tag
Met -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Ile 0	-	expression tag
Pro 1	-	expression tag
Thr 1151	Lys 1151	conflict
Leu 2512	-	expression tag
Glu 2513	-	expression tag
His 2514	-	expression tag
His 2515	-	expression tag
His 2516	-	expression tag
His 2517	-	expression tag
His 2518	-	expression tag
His 2519	-	expression tag
His 2520	-	expression tag
His 2521	-	expression tag

B: 2 - 2511 (UniProt: P49327)

PDB	External Database	Details
Met -31	-	initiating methionine
Ser -30	-	expression tag
Tyr -29	-	expression tag
Tyr -28	-	expression tag
Asp -27	-	expression tag
Tyr -26	-	expression tag
Lys -25	-	expression tag
Asp -24	-	expression tag
Asp -23	-	expression tag
Asp -22	-	expression tag
Asp -21	-	expression tag
Lys -20	-	expression tag
Asp -19	-	expression tag
Tyr -18	-	expression tag
Asp -17	-	expression tag
Ile -16	-	expression tag
Pro -15	-	expression tag
Thr -14	-	expression tag
Thr -13	-	expression tag
Glu -12	-	expression tag
Asn -11	-	expression tag
Leu -10	-	expression tag
Tyr -9	-	expression tag
Phe -8	-	expression tag
Gln -7	-	expression tag
Gly -6	-	expression tag
Ala -5	-	expression tag
Met -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Ile 0	-	expression tag
Pro 1	-	expression tag
Thr 1151	Lys 1151	conflict
Leu 2512	-	expression tag
Glu 2513	-	expression tag
His 2514	-	expression tag
His 2515	-	expression tag
His 2516	-	expression tag
His 2517	-	expression tag
His 2518	-	expression tag
His 2519	-	expression tag
His 2520	-	expression tag
His 2521	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	557784.8
Non-Polymers*	Number of molecules	4
	Total formula weight	2981.7
All*	Total formula weight	560766.5

*Water molecules are not included.