8VDD
Crystal structure of Proinsulin C-peptide bound to HLA-DQ8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MHC class II HLA-DQ-alpha chain | polymer | 185 | 21124.5 | 1 | UniProt (Q30069) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | DQA1*03:01 (DQ8-alpha chain) |
| 2 | B (B) | MHC class II HLA-DQ-beta-1 | polymer | 192 | 22605.4 | 1 | UniProt (O19707) Pfam (PF00969) Pfam (PF07654) | Homo sapiens (human) | DQB1*03:02 (DQ8-beta chain) |
| 3 | C (C) | Proinsulin C-peptide (InsC8-22) | polymer | 15 | 1388.5 | 1 | UniProt (P01308) | Homo sapiens (human) | |
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | F, G, H (A, B, C) | water | water | 18.0 | 52 | Chemie (HOH) |
Sequence modifications
A: -1 - 182 (UniProt: Q30069)
C: -2 - 12 (UniProt: P01308)
| PDB | External Database | Details |
|---|---|---|
| Cys 73 | Ile 75 | engineered mutation |
| Ser 183 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 9 | Gly 75 | engineered mutation |
| Cys 11 | Leu 77 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 45118.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 313.3 | |
| All* | Total formula weight | 45431.7 |
