8VCX

Human TCR A2.13 in complex with DQ8-InsCpep

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (D)	T-CELL-RECEPTOR, TCR A2.13 alpha	polymer	203	22633.2	1		Homo sapiens (human)
2	B (E)	T-CELL-RECEPTOR, A2.13-beta chain	polymer	239	27076.1	1		Homo sapiens (human)
3	C (A)	MHC class II HLA-DQ-alpha chain	polymer	185	21150.6	1	UniProt (Q30069) Pfam (PF00993) Pfam (PF07654)	Homo sapiens (human)	DQA1*03:01 (DQ8-alpha chain)
4	D (B)	MHC class II HLA-DQ-beta-1	polymer	192	22605.4	1	UniProt (O19707) Pfam (PF00969) Pfam (PF07654)	Homo sapiens (human)	DQB1*03:02 (DQ8-beta chain)
5	E (C)	Proinsulin C-peptide (InsC8-22)	polymer	15	1388.5	1	UniProt (P01308)	Homo sapiens (human)
6	F (F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
7	G, H (G, H)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
8	I (D)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
9	J, K, L, M, N (D, E, B)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
10	O, P, Q, R, S (D, E, A, B, C)	water	water		18.0	78	Chemie (HOH)

Sequence modifications

A: -1 - 182 (UniProt: Q30069)

PDB	External Database	Details
Cys 72	Ile 75	engineered mutation

C: -2 - 12 (UniProt: P01308)

PDB	External Database	Details
Glu 9	Gly 75	engineered mutation
Cys 11	Leu 77	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	94853.8
Branched	Number of molecules	3
	Total formula weight	1419.3
Non-Polymers*	Number of molecules	6
	Total formula weight	555.4
All*	Total formula weight	96828.5

*Water molecules are not included.