8VCX
Human TCR A2.13 in complex with DQ8-InsCpep
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | D | T-CELL-RECEPTOR, TCR A2.13 alpha | polymer | 203 | 22633.2 | 1 | Homo sapiens (human) | ||
| 2 | E | T-CELL-RECEPTOR, A2.13-beta chain | polymer | 239 | 27076.1 | 1 | Homo sapiens (human) | ||
| 3 | A | MHC class II HLA-DQ-alpha chain | polymer | 185 | 21150.6 | 1 | UniProt (Q30069) In PDB | Homo sapiens (human) | DQA1*03:01 (DQ8-alpha chain) |
| 4 | B | MHC class II HLA-DQ-beta-1 | polymer | 192 | 22605.4 | 1 | UniProt (O19707) In PDB | Homo sapiens (human) | DQB1*03:02 (DQ8-beta chain) |
| 5 | C | Proinsulin C-peptide (InsC8-22) | polymer | 15 | 1388.5 | 1 | UniProt (P01308) In PDB | Homo sapiens (human) | |
| 6 | F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 7 | G, H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 8 | D | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 9 | D, E, B | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 10 | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A: -1 - 182 (UniProt: Q30069)
C: -2 - 12 (UniProt: P01308)
| PDB | External Database | Details |
|---|---|---|
| Cys 72 | Ile 75 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Glu 9 | Gly 75 | engineered mutation |
| Cys 11 | Leu 77 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 94853.8 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1419.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 555.4 | |
| All* | Total formula weight | 96828.5 |
