8VCF

Crystal structure of Superbinder Src SH2 domain with Cysteine to Serine mutations

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Isoform 3 of Proto-oncogene tyrosine-protein kinase Src	polymer	127	14407.1	1	UniProt (P12931) Pfam (PF00017)	Homo sapiens (human)	Proto-oncogene c-Src,pp60c-src,p60-Src
2	B (A)	water	water		18.0	120	Chemie (HOH)

Sequence modifications

A: 144 - 251 (UniProt: P12931)

PDB	External Database	Details
Met 125	-	initiating methionine
Gly 126	-	expression tag
Ser 127	-	expression tag
Ser 128	-	expression tag
His 129	-	expression tag
His 130	-	expression tag
His 131	-	expression tag
His 132	-	expression tag
His 133	-	expression tag
His 134	-	expression tag
Gly 135	-	expression tag
Leu 136	-	expression tag
Val 137	-	expression tag
Pro 138	-	expression tag
Arg 139	-	expression tag
Gly 140	-	expression tag
Ser 141	-	expression tag
His 142	-	expression tag
Met 143	-	expression tag
Val 183	Thr 200	conflict
Ala 188	Cys 205	conflict
Leu 206	Lys 223	conflict
Ser 241	Cys 258	conflict
Ser 248	Cys 265	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	14407.1
All*	Total formula weight	14407.1

*Water molecules are not included.