8VBY
Structure of the human dopamine transporter in complex with beta-CFT, MRS7292 and divalent zinc
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium-dependent dopamine transporter | polymer | 571 | 63384.5 | 1 | UniProt (Q01959) Pfam (PF00209) | Homo sapiens (human) | |
| 2 | B (A) | methyl (1R,2S,3S,5S)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate | non-polymer | 277.3 | 1 | Chemie (42L) | |||
| 3 | C (A) | methyl (1S,2R,3S,4R,5R)-4-{2-[(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)-9H-purin-9-yl}-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate | non-polymer | 459.9 | 1 | Chemie (A1AAF) | |||
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E, K, L, MA (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) | |||
| 6 | F, H, IA, JA, OA... (A) | DECANE | non-polymer | 142.3 | 8 | Chemie (D10) | |||
| 7 | G, GA, I, J, V... (A) | PENTANE | non-polymer | 72.1 | 7 | Chemie (LNK) | |||
| 8 | BA, FA, HA, LA, M... (A) | HEPTANE | non-polymer | 100.2 | 8 | Chemie (HP6) | |||
| 9 | N (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 10 | O (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 11 | AA, CA, KA, NA, Q... (A) | DODECANE | non-polymer | 170.3 | 6 | Chemie (D12) | |||
| 12 | Z (A) | PENTADECANE | non-polymer | 212.4 | 1 | Chemie (MYS) | |||
| 13 | DA, EA (A) | N-OCTANE | non-polymer | 114.2 | 2 | Chemie (OCT) | |||
| 14 | QA (A) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 57 - 620 (UniProt: Q01959)
| PDB | External Database | Details |
|---|---|---|
| Gly 51 | - | expression tag |
| Pro 52 | - | expression tag |
| Gly 53 | - | expression tag |
| Gly 54 | - | expression tag |
| Arg 55 | - | expression tag |
| Met 56 | - | expression tag |
| Tyr 248 | Ile 248 | engineered mutation |
| Ile 621 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 63384.5 | |
| Non-Polymers* | Number of molecules | 41 |
| Total formula weight | 6901.5 | |
| All* | Total formula weight | 70286.0 |
