8VBY
Structure of the human dopamine transporter in complex with beta-CFT, MRS7292 and divalent zinc
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium-dependent dopamine transporter | polymer | 571 | 63384.5 | 1 | UniProt (Q01959) Pfam (PF00209) | Homo sapiens (human) | |
| 2 | B (A) | methyl (1R,2S,3S,5S)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate | non-polymer | 277.3 | 1 | Chemie (42L) PubChem (21117976) PubChem (24148552) PubChem (44273801) PubChem (44286424) PubChem (44345529) PubChem (44421414) PubChem (44462220) PubChem (18656964) PubChem (105056) PubChem (206161) PubChem (57176020) PubChem (44461339) PubChem (67781854) PubChem (69486633) PubChem (70689263) PubChem (70697274) PubChem (10755007) PubChem (6918292) PubChem (98094965) PubChem (100960183) PubChem (101082428) PubChem (10468744) PubChem (10564483) PubChem (10707673) PubChem (10850151) PubChem (11780820) PubChem (11959454) PubChem (11959455) PubChem (124524822) PubChem (124527853) PubChem (14831995) PubChem (144586257) | |||
| 3 | C (A) | methyl (1S,2R,3S,4R,5R)-4-{2-[(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)-9H-purin-9-yl}-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate | non-polymer | 459.9 | 1 | Chemie (A1AAF) PubChem (168280139) PubChem (137633601) | |||
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E, K, L, MA (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (45489984) PubChem (363416) PubChem (60078761) PubChem (500055) PubChem (73440805) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (99567469) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (13301926) PubChem (13301927) PubChem (124914595) PubChem (124914596) PubChem (155804219) PubChem (169132514) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 6 | F, H, IA, JA, OA... (A) | DECANE | non-polymer | 142.3 | 8 | Chemie (D10) PubChem (15600) | |||
| 7 | G, GA, I, J, V... (A) | PENTANE | non-polymer | 72.1 | 7 | Chemie (LNK) PubChem (8003) | |||
| 8 | BA, FA, HA, LA, M... (A) | HEPTANE | non-polymer | 100.2 | 8 | Chemie (HP6) PubChem (8900) | |||
| 9 | N (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 10 | O (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 11 | AA, CA, KA, NA, Q... (A) | DODECANE | non-polymer | 170.3 | 6 | Chemie (D12) PubChem (8182) PubChem (5359624) | |||
| 12 | Z (A) | PENTADECANE | non-polymer | 212.4 | 1 | Chemie (MYS) PubChem (12391) | |||
| 13 | DA, EA (A) | N-OCTANE | non-polymer | 114.2 | 2 | Chemie (OCT) PubChem (356) | |||
| 14 | QA (A) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 57 - 620 (UniProt: Q01959)
| PDB | External Database | Details |
|---|---|---|
| Gly 51 | - | expression tag |
| Pro 52 | - | expression tag |
| Gly 53 | - | expression tag |
| Gly 54 | - | expression tag |
| Arg 55 | - | expression tag |
| Met 56 | - | expression tag |
| Tyr 248 | Ile 248 | engineered mutation |
| Ile 621 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 63384.5 | |
| Non-Polymers* | Number of molecules | 41 |
| Total formula weight | 6901.5 | |
| All* | Total formula weight | 70286.0 |
