8VA5
Menin mutant - T349M in complex with Ziftomenib (KO-539)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Menin | polymer | 489 | 54630.3 | 1 | UniProt (O00255) Pfam (PF05053) | Homo sapiens (human) | |
| 2 | B (A) | Ziftomenib | non-polymer | 717.9 | 1 | Chemie (K5O) | |||
| 3 | C, E (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 4 | D (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 5 | F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | G, H (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 7 | I (A) | water | water | 18.0 | 634 | Chemie (HOH) |
Sequence modifications
A: 1 - 459 (UniProt: O00255)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| - | Ile 54 | deletion |
| - | Pro 55 | deletion |
| - | Thr 56 | deletion |
| - | Asn 57 | deletion |
| - | Val 58 | deletion |
| - | Pro 59 | deletion |
| - | Glu 60 | deletion |
| - | Leu 61 | deletion |
| - | Thr 62 | deletion |
| - | Phe 63 | deletion |
| - | Gln 64 | deletion |
| - | Pro 65 | deletion |
| - | Ser 66 | deletion |
| - | Pro 67 | deletion |
| - | Ala 68 | deletion |
| - | Pro 69 | deletion |
| - | Asp 70 | deletion |
| - | Pro 71 | deletion |
| - | Pro 72 | deletion |
| - | Gly 73 | deletion |
| Met 344 | Thr 344 | engineered mutation |
| - | Glu 387 | deletion |
| - | Glu 388 | deletion |
| - | Arg 389 | deletion |
| - | Pro 390 | deletion |
| - | Gly 391 | deletion |
| - | Glu 392 | deletion |
| - | Gln 393 | deletion |
| - | Ser 394 | deletion |
| - | Gln 395 | deletion |
| - | Gly 396 | deletion |
| - | Thr 397 | deletion |
| - | Gln 398 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 54630.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1342.7 | |
| All* | Total formula weight | 55973.0 |
