8V81
Phosphorylated, ATP-bound, inhibitor 172-bound E1371Q human cystic fibrosis transmembrane conductance regulator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cystic fibrosis transmembrane conductance regulator | polymer | 1438 | 163494.1 | 1 | UniProt (P13569) In PDB | Homo sapiens (human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | A | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 4 | A | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 5 | Chemie (POV) | |||
| 5 | A | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 6 | A | 4-[(Z)-{(3M)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid | non-polymer | 409.4 | 1 | Chemie (WG5) |
Sequence modifications
A: 3 - 1440 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Pro 492 | Ser 492 | conflict |
| Pro 495 | Ser 495 | conflict |
| Pro 534 | Ala 534 | conflict |
| Thr 539 | Ile 539 | conflict |
| Lys 555 | Arg 555 | conflict |
| Gln 1371 | Glu 1371 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 163494.1 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 5659.4 | |
| All* | Total formula weight | 169153.5 |
