8V77
Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with compound 12
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Inositol polyphosphate multikinase | polymer | 261 | 29827.9 | 1 | UniProt (Q8NFU5) Pfam (PF03770) | Homo sapiens (human) | Inositol 1,3,4,6-tetrakisphosphate 5-kinase |
| 2 | B (A) | (3P,5P)-3-{3-[(piperidin-4-yl)oxy]phenyl}-5-(2H-tetrazol-5-yl)-2,1-benzoxazole | non-polymer | 362.4 | 1 | Chemie (YJ3) | |||
| 3 | C (A) | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
A: 50 - 372 (UniProt: Q8NFU5)
A: 378 - 416 (UniProt: Q8NFU5)
| PDB | External Database | Details |
|---|---|---|
| Gly 46 | - | expression tag |
| Ser 47 | - | expression tag |
| Phe 48 | - | expression tag |
| Thr 49 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 373 | - | linker |
| Gly 374 | - | linker |
| Ser 375 | - | linker |
| Gly 376 | - | linker |
| Gly 377 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29827.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 362.4 | |
| All* | Total formula weight | 30190.3 |
