8V60
F315A mutant of human Slo1 in presence of EDTA - resting VSD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Calcium-activated potassium channel subunit alpha-1 | polymer | 1065 | 119912.0 | 4 | UniProt (Q12791) Pfam (PF00520) Pfam (PF22614) Pfam (PF03493) Pfam (PF21014) | Homo sapiens (human) | BK channel,BKCA alpha,Calcium-activated potassium channel,subfamily M subunit alpha-1,K(VCA)alpha,KCa1.1,Maxi K channel,MaxiK,Slo-alpha,Slo1,Slowpoke homolog,Slo homolog,hSlo |
| 2 | E, F, G, H, I... (A, B, D, C) | POTASSIUM ION | non-polymer | 39.1 | 9 | Chemie (K) | |||
| 3 | AA, BA, CA, DA, EA... (B, A, D, C) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 28 | Chemie (POV) | |||
| 4 | AB, JA, Q, TB (C, B, A, D) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) | |||
| 5 | AC, BB, BC, CB, CC... (D, C, B, A) | Digitonin | non-polymer | 1229.3 | 36 | Chemie (AJP) | |||
| 6 | DC, EC, FC, GC (A, B, C, D) | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 1056 (UniProt: Q12791)
| PDB | External Database | Details |
|---|---|---|
| Ala 315 | Phe 380 | engineered mutation |
| Ser 1057 | - | expression tag |
| Asn 1058 | - | expression tag |
| Ser 1059 | - | expression tag |
| Leu 1060 | - | expression tag |
| Glu 1061 | - | expression tag |
| Val 1062 | - | expression tag |
| Leu 1063 | - | expression tag |
| Phe 1064 | - | expression tag |
| Gln 1065 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 479647.9 | |
| Non-Polymers* | Number of molecules | 77 |
| Total formula weight | 67435.9 | |
| All* | Total formula weight | 547083.7 |
