8V5K

Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 4C03 and 4C06

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, E (A, B, C)	Fusion glycoprotein F0	polymer	498	55365.0	3	UniProt (T1UCV5) Pfam (PF00523) UniProt (by SIFTS) (A0A023PFZ0)	Human respirovirus 3
2	B, F, G (D, E, F)	Camelid Nanobody 4C03	polymer	124	13726.4	3		Lama glama
3	C, H, I (G, H, I)	Camelid Nanobody 4C06	polymer	117	12487.8	3		Lama glama
4	J, K, L (A, B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)

Sequence modifications

A, B, C: 19 - 484 (UniProt: T1UCV5)

PDB	External Database	Details
Pro 165	Ile 165	conflict
Cys 186	Ser 186	conflict
Cys 195	Ala 195	conflict
Leu 198	Gln 198	conflict
Leu 201	Ile 201	conflict
Asp 204	Thr 204	conflict
Asn 452	Asp 452	conflict
Glu 485	-	expression tag
Asp 486	-	expression tag
Lys 487	-	expression tag
Ile 488	-	expression tag
Glu 489	-	expression tag
Glu 490	-	expression tag
Ile 491	-	expression tag
Leu 492	-	expression tag
Ser 493	-	expression tag
Lys 494	-	expression tag
Ile 495	-	expression tag
Tyr 496	-	expression tag
His 497	-	expression tag
Ile 498	-	expression tag
Glu 499	-	expression tag
Asn 500	-	expression tag
Glu 501	-	expression tag
Ile 502	-	expression tag
Ala 503	-	expression tag
Arg 504	-	expression tag
Ile 505	-	expression tag
Lys 506	-	expression tag
Lys 507	-	expression tag
Leu 508	-	expression tag
Ile 509	-	expression tag
Gly 510	-	expression tag
Glu 511	-	expression tag
Ala 512	-	expression tag
Glu 513	-	expression tag
Pro 514	-	expression tag
Glu 515	-	expression tag
Ala 516	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	244737.5
Non-Polymers*	Number of molecules	3
	Total formula weight	663.6
All*	Total formula weight	245401.1

*Water molecules are not included.