8V5I
Crystal structure of MAP4K4 in complex with an inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase kinase kinase kinase 4 | polymer | 320 | 36772.3 | 2 | UniProt (O95819) Pfam (PF00069) | Homo sapiens (human) | HPK/GCK-like kinase HGK,MAPK/ERK kinase kinase kinase 4,MEK kinase kinase 4,MEKKK 4,Nck-interacting kinase |
| 2 | C (A) | (3M)-N~6~-(1,4-dimethyl-1H-pyrazol-3-yl)-3-(1-methyl-1H-imidazol-5-yl)-2,7-naphthyridine-1,6-diamine | non-polymer | 334.4 | 1 | Chemie (A1AAA) |
Sequence modifications
A, B: 1 - 313 (UniProt: O95819)
| PDB | External Database | Details |
|---|---|---|
| Leu 314 | - | expression tag |
| Glu 315 | - | expression tag |
| Asn 316 | - | expression tag |
| Leu 317 | - | expression tag |
| Tyr 318 | - | expression tag |
| Phe 319 | - | expression tag |
| Gln 320 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73544.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 334.4 | |
| All* | Total formula weight | 73878.9 |
