8V39
Crystal structure of active KRAS-G12C (GMPPNP-bound) in complex with BBO-8520
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | GTPase KRas | polymer | 170 | 19358.8 | 3 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | D, G, J (A, B, C) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 3 | Chemie (GNP) | |||
| 3 | E, H, K (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | F, I, L (A, B, C) | BBO-8520 (bound form) | non-polymer | 731.8 | 3 | Chemie (Y8N) | |||
| 5 | M, N, O (A, B, C) | water | water | 18.0 | 303 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Cys 12 | Gly 12 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 58076.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 3834.8 | |
| All* | Total formula weight | 61911.3 |
