8V2B

Cryo-EM structure of mouse type II OSM receptor complex: model for full extracellular assembly

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Oncostatin-M	polymer	183	20645.2	1	UniProt (P53347) Pfam (PF01291)	Mus musculus (house mouse)
2	B (B)	Interleukin-6 receptor subunit beta	polymer	623	70033.6	1	UniProt (Q00560) Pfam (PF06328) Pfam (PF09240) Pfam (PF00041)	Mus musculus (house mouse)
3	C (C)	Oncostatin-M-specific receptor subunit beta	polymer	715	82357.7	1	UniProt (O70458) Pfam (PF17971) Pfam (PF21177) Pfam (PF00041)	Mus musculus (house mouse)
4	D, E, F, G, H... (D, E, F, G, H...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	11	In PDB GlyTouCan (G42666HT)
5	O, P, Q, R, S... (B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)

Sequence modifications

B: 23 - 617 (UniProt: Q00560)

PDB	External Database	Details
Glu 618	-	expression tag
Gln 619	-	expression tag
Lys 620	-	expression tag
Leu 621	-	expression tag
Ile 622	-	expression tag
Ser 623	-	expression tag
Glu 624	-	expression tag
Glu 625	-	expression tag
Asp 626	-	expression tag
Leu 627	-	expression tag
Gly 628	-	expression tag
Gly 629	-	expression tag
Glu 630	-	expression tag
Gln 631	-	expression tag
Lys 632	-	expression tag
Leu 633	-	expression tag
Ile 634	-	expression tag
Ser 635	-	expression tag
Glu 636	-	expression tag
Glu 637	-	expression tag
Asp 638	-	expression tag
Leu 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag
His 644	-	expression tag
His 645	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	173036.5
Branched	Number of molecules	11
	Total formula weight	4668.4
Non-Polymers*	Number of molecules	7
	Total formula weight	1548.5
All*	Total formula weight	179253.4

*Water molecules are not included.