8V1T
Herpes simplex virus 1 polymerase holoenzyme bound to DNA and acyclovir triphosphate in closed conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase | polymer | 1199 | 133614.3 | 1 | UniProt (H9E937) Pfam (PF03104) Pfam (PF00136) Pfam (PF11590) | Human alphaherpesvirus 1 strain KOS | |
| 2 | B (B) | DNA polymerase processivity factor | polymer | 340 | 36346.2 | 1 | UniProt (H9E949) Pfam (PF02282) | Human alphaherpesvirus 1 strain KOS | Polymerase accessory protein |
| 3 | C (P) | PRIMER DNA (32-MER) | polymer | 32 | 9866.4 | 1 | synthetic construct | ||
| 4 | D (T) | TEMPLATE DNA (50-MER) | polymer | 50 | 15199.8 | 1 | synthetic construct | ||
| 5 | E, F, G, H (A) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 6 | I (A) | ACYCLOVIR TRIPHOSPHATE | non-polymer | 465.1 | 1 | Chemie (AVP) | |||
| 7 | J (A) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 43 - 1235 (UniProt: H9E937)
| PDB | External Database | Details |
|---|---|---|
| His 37 | - | expression tag |
| His 38 | - | expression tag |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| His 41 | - | expression tag |
| His 42 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 195026.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 562.4 | |
| All* | Total formula weight | 195589.0 |
