8V1T

Herpes simplex virus 1 polymerase holoenzyme bound to DNA and acyclovir triphosphate in closed conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	DNA polymerase	polymer	1199	133614.3	1	UniProt (H9E937) In PDB	Human alphaherpesvirus 1 strain KOS
2	B	DNA polymerase processivity factor	polymer	340	36346.2	1	UniProt (H9E949) In PDB	Human alphaherpesvirus 1 strain KOS	Polymerase accessory protein
3	P	PRIMER DNA (32-MER)	polymer	32	9866.4	1		synthetic construct
4	T	TEMPLATE DNA (50-MER)	polymer	50	15199.8	1		synthetic construct
5	A	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
6	A	ACYCLOVIR TRIPHOSPHATE	non-polymer		465.1	1	Chemie (AVP)
7		water	water		18.0	4	Chemie (HOH)

Sequence modifications

A: 43 - 1235 (UniProt: H9E937)

PDB	External Database	Details
His 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	195026.6
Non-Polymers*	Number of molecules	5
	Total formula weight	562.4
All*	Total formula weight	195589.0

*Water molecules are not included.