8V1Q
Herpes simplex virus 1 polymerase holoenzyme bound to DNA in both open/closed conformations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase | polymer | 1199 | 133614.3 | 1 | UniProt (H9E937) Pfam (PF03104) Pfam (PF00136) Pfam (PF11590) | Human alphaherpesvirus 1 strain KOS | |
| 2 | B (B) | DNA polymerase processivity factor | polymer | 349 | 37275.1 | 1 | UniProt (A0A181ZFK4) Pfam (PF02282) | Human alphaherpesvirus 1 strain KOS | |
| 3 | C (P) | Primer DNA | polymer | 32 | 9866.4 | 1 | synthetic construct | ||
| 4 | D (T) | template DNA | polymer | 50 | 15223.8 | 1 | synthetic construct | ||
| 5 | E, F (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | G (A) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 43 - 1235 (UniProt: H9E937)
B: 2 - 340 (UniProt: A0A181ZFK4)
| PDB | External Database | Details |
|---|---|---|
| His 37 | - | expression tag |
| His 38 | - | expression tag |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| His 41 | - | expression tag |
| His 42 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -8 | - | expression tag |
| Pro -7 | - | expression tag |
| Ile -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Glu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Arg 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 195979.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 48.6 | |
| All* | Total formula weight | 196028.2 |
