8V1O
Crystal structure of IRAK4 kinase domain with compound 4
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Interleukin-1 receptor-associated kinase 4 | polymer | 327 | 37201.7 | 4 | UniProt (Q9NWZ3) In PDB | Homo sapiens (human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
2 | A, B, C, D | N-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | non-polymer | 450.5 | 4 | Chemie (Y9T) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
4 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
5 | D | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
6 | water | water | 18.0 | 118 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 160 - 460 (UniProt: Q9NWZ3)
PDB | External Database | Details |
---|---|---|
Met 134 | - | initiating methionine |
Ser 135 | - | expression tag |
Tyr 136 | - | expression tag |
Tyr 137 | - | expression tag |
His 138 | - | expression tag |
His 139 | - | expression tag |
His 140 | - | expression tag |
His 141 | - | expression tag |
His 142 | - | expression tag |
His 143 | - | expression tag |
Asp 144 | - | expression tag |
Tyr 145 | - | expression tag |
Asp 146 | - | expression tag |
Ile 147 | - | expression tag |
Pro 148 | - | expression tag |
Thr 149 | - | expression tag |
Thr 150 | - | expression tag |
Glu 151 | - | expression tag |
Asn 152 | - | expression tag |
Leu 153 | - | expression tag |
Tyr 154 | - | expression tag |
Phe 155 | - | expression tag |
Gln 156 | - | expression tag |
Ser 157 | - | expression tag |
Ile 158 | - | expression tag |
Ala 159 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 148806.7 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2117.5 | |
All* | Total formula weight | 150924.2 |