8V0Z
HIV-1 Integrase F185H W131C Complexed with Allosteric Inhibitor BI-D
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Integrase | polymer | 293 | 32661.3 | 2 | UniProt (P12497) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552) | Human immunodeficiency virus 1 | IN |
| 2 | C, D (A, B) | (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid | non-polymer | 405.5 | 2 | Chemie (LF0) |
Sequence modifications
A, B: 2 - 288 (UniProt: P12497)
| PDB | External Database | Details |
|---|---|---|
| His 1 | - | cloning artifact |
| Ala 15 | Tyr 1162 | engineered mutation |
| Cys 131 | Trp 1278 | engineered mutation |
| His 185 | Phe 1332 | engineered mutation |
| Cys 289 | - | expression tag |
| Thr 290 | - | expression tag |
| Leu 291 | - | expression tag |
| Glu 292 | - | expression tag |
| Tyr 293 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65322.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 811.0 | |
| All* | Total formula weight | 66133.5 |
