8UZJ
Alpha7-nicotinic acetylcholine receptor bound to epibatidine and ivermectin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Neuronal acetylcholine receptor subunit alpha-7,Soluble cytochrome b562 | polymer | 599 | 67220.8 | 5 | UniProt (P36544) UniProt (P0ABE7) Pfam (PF02931) Pfam (PF02932) Pfam (PF07361) | Homo sapiens (human) | Cytochrome b-562 |
| 2 | F, H, J, L, N (F, H, J, L, N) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 5 | In PDB GlyTouCan (G15407YE) | |||
| 3 | G, I, K, M, O (G, I, K, M, O) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 4 | DA, JA, P, PA, X (C, D, A, E, B) | CALCIUM ION | non-polymer | 40.1 | 5 | Chemie (CA) | |||
| 5 | EA, KA, Q, QA, Y (C, D, A, E, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 6 | FA, LA, R, RA, Z (C, D, A, E, B) | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en | non-polymer | 544.8 | 5 | Chemie (9Z9) | |||
| 7 | AA, GA, MA, S, SA (B, C, D, A, E) | EPIBATIDINE | non-polymer | 208.7 | 5 | Chemie (EPJ) | |||
| 8 | BA, HA, NA, T, V (C, D, E, A, B) | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside | non-polymer | 875.1 | 5 | Chemie (IVM) | |||
| 9 | CA, IA, OA, U, W (C, D, E, A, B) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 5 | Chemie (POV) | |||
| 10 | TA, UA, VA, WA, XA (A, B, C, D, E) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 324 (UniProt: P36544)
A, B, C, D, E: 328 - 479 (UniProt: P36544)
A, B, C, D, E: 324 - 328 (UniProt: P0ABE7)
| PDB | External Database | Details |
|---|---|---|
| - | Ser 368 | deletion |
| - | Val 369 | deletion |
| - | Glu 370 | deletion |
| - | Met 371 | deletion |
| - | Ser 372 | deletion |
| - | Ala 373 | deletion |
| - | Val 374 | deletion |
| - | Ala 375 | deletion |
| - | Pro 376 | deletion |
| - | Pro 377 | deletion |
| - | Pro 378 | deletion |
| - | Ala 379 | deletion |
| - | Ser 380 | deletion |
| - | Asn 381 | deletion |
| - | Gly 382 | deletion |
| - | Asn 383 | deletion |
| - | Leu 384 | deletion |
| - | Leu 385 | deletion |
| - | Tyr 386 | deletion |
| - | Ile 387 | deletion |
| - | Gly 388 | deletion |
| - | Phe 389 | deletion |
| - | Arg 390 | deletion |
| - | Gly 391 | deletion |
| - | Leu 392 | deletion |
| - | Asp 393 | deletion |
| - | Gly 394 | deletion |
| - | Val 395 | deletion |
| - | His 396 | deletion |
| - | Cys 397 | deletion |
| - | Val 398 | deletion |
| - | Pro 399 | deletion |
| - | Thr 400 | deletion |
| - | Pro 401 | deletion |
| - | Asp 402 | deletion |
| - | Ser 403 | deletion |
| - | Gly 404 | deletion |
| - | Val 405 | deletion |
| - | Val 406 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Ala 324 | - | linker |
| Gly 324 | - | linker |
| Ala 324 | - | linker |
| Met 324 | - | linker |
| Trp 480 | - | expression tag |
| Ser 481 | - | expression tag |
| His 482 | - | expression tag |
| Pro 483 | - | expression tag |
| Gln 484 | - | expression tag |
| Phe 485 | - | expression tag |
| Glu 486 | - | expression tag |
| Lys 487 | - | expression tag |
| Gly 488 | - | linker |
| Gly 489 | - | linker |
| Gly 490 | - | linker |
| Ser 491 | - | linker |
| Gly 492 | - | linker |
| Gly 493 | - | linker |
| Gly 494 | - | linker |
| Ser 495 | - | linker |
| Gly 496 | - | linker |
| Gly 497 | - | linker |
| Ser 498 | - | linker |
| Ser 499 | - | linker |
| Ala 500 | - | linker |
| Trp 501 | - | expression tag |
| Ser 502 | - | expression tag |
| His 503 | - | expression tag |
| Pro 504 | - | expression tag |
| Gln 505 | - | expression tag |
| Phe 506 | - | expression tag |
| Glu 507 | - | expression tag |
| Lys 508 | - | expression tag |
| Gly 509 | - | linker |
| Ser 510 | - | linker |
| Gly 511 | - | linker |
| Glu 512 | - | linker |
| Gly 513 | - | linker |
| Arg 514 | - | linker |
| Gly 515 | - | linker |
| Ser 516 | - | linker |
| Leu 517 | - | linker |
| Leu 518 | - | linker |
| Thr 519 | - | linker |
| Cys 520 | - | linker |
| Gly 521 | - | linker |
| Asp 522 | - | linker |
| Val 523 | - | linker |
| Glu 524 | - | linker |
| Glu 525 | - | linker |
| Asn 526 | - | linker |
| Pro 527 | - | linker |
| Gly 528 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Trp 324 | Met 29 | conflict |
| Ile 328 | His 124 | conflict |
| Leu 328 | Arg 128 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 336104.0 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 5054.7 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 13249.7 | |
| All* | Total formula weight | 354408.4 |
