8UY2
Methylenetetrahydrofolate reductase from Chaetomium thermophilum DSM 1495, AdoMet-bound, Inhibited (T) State
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Methylenetetrahydrofolate reductase-like protein | polymer | 617 | 70256.5 | 4 | UniProt (G0S5U9) Pfam (PF02219) Pfam (PF21895) | Thermochaetoides thermophila DSM 1495 | |
| 2 | BA, E, L, U (D, A, B, C) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 4 | Chemie (FAD) | |||
| 3 | CA, DA, F, G, M... (D, A, B, C) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 8 | Chemie (SAM) | |||
| 4 | H, I, O, X (A, B, C) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 5 | AA, EA, FA, J, Q... (C, D, A, B) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 6 | K (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 7 | P, Y (B, C) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 8 | GA, HA, IA, JA (A, B, C, D) | water | water | 18.0 | 335 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 614 (UniProt: G0S5U9)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Ala 315 | Arg 315 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 281026.1 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 7637.6 | |
| All* | Total formula weight | 288663.7 |
