8UXQ

Structure of Heterochromatin Protein 1 (HP1) alpha in complex with an H2A.Z nucleosome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, C)	Chromobox protein homolog 5	polymer	195	22651.4	2	UniProt (P45973) Pfam (PF00385) Pfam (PF01393)	Homo sapiens (human)	Antigen p25,Heterochromatin protein 1 homolog alpha,HP1 alpha
2	C, G (E, K)	Histone H3.2	polymer	135	15303.9	2	UniProt (P84233) Pfam (PF00125)	Xenopus laevis (African clawed frog)	Histone H3
3	D, H (F, L)	Histone H4	polymer	102	11263.2	2	UniProt (P62799) Pfam (PF15511)	Xenopus laevis (African clawed frog)
4	E, I (G, M)	Histone H2A.Z	polymer	127	13450.6	2	UniProt (P0C0S6) Pfam (PF00125) Pfam (PF16211)	Mus musculus (house mouse)	H2A/z
5	F, J (H, N)	Histone H2B 1.1	polymer	125	13848.1	2	UniProt (P02281) Pfam (PF00125)	Xenopus laevis (African clawed frog)	H2B1.1
6	K (I)	DNA Widom601 (208bp) strand1	polymer	208	64456.0	1		synthetic construct
7	L (J)	DNA Widom601 (208bp) strand2	polymer	208	63988.7	1		synthetic construct

Sequence modifications

A, C: -19 - 170 (UniProt: P45973)

PDB	External Database	Details
Gly -24	-	expression tag
Ser -23	-	expression tag
Pro -22	-	expression tag
Glu -21	-	expression tag
Phe -20	-	expression tag

E, K: 289 - 423 (UniProt: P84233)

PDB	External Database	Details
Ala 390	Gly 103	variant

H, N: 587 - 711 (UniProt: P02281)

PDB	External Database	Details
Thr 618	Ser 33	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	281479.3
All*	Total formula weight	281479.3

*Water molecules are not included.