8UTV
KIF1A[1-393] P305L mutant ADP bound in complex with a microtubule
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (E, A) | Tubulin alpha-1B chain | polymer | 451 | 50204.4 | 2 | UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (pig) | Alpha-tubulin ubiquitous, Tubulin K-alpha-1, Tubulin alpha-ubiquitous chain |
| 2 | C (B) | Tubulin beta-2B chain | polymer | 445 | 49999.9 | 1 | UniProt (A0A287AGU7) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (pig) | |
| 3 | D (K) | Kinesin-like protein KIF1A | polymer | 438 | 49304.5 | 1 | UniProt (Q12756) Pfam (PF00225) | Homo sapiens (human) | |
| 4 | E, G (E, A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
| 5 | F, H (E, A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | I (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 7 | J (B) | TAXOL | non-polymer | 853.9 | 1 | Chemie (TA1) | |||
| 8 | K (K) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) |
Sequence modifications
K: 1 - 393 (UniProt: Q12756)
| PDB | External Database | Details |
|---|---|---|
| Leu 305 | Pro 305 | engineered mutation |
| Gly 394 | - | linker |
| Ala 395 | - | linker |
| Gly 396 | - | linker |
| Val 397 | - | linker |
| Lys 398 | - | linker |
| Gln 399 | - | linker |
| Leu 400 | - | linker |
| Glu 401 | - | linker |
| Asp 402 | - | linker |
| Lys 403 | - | linker |
| Val 404 | - | linker |
| Glu 405 | - | linker |
| Glu 406 | - | linker |
| Leu 407 | - | linker |
| Ala 408 | - | linker |
| Ser 409 | - | linker |
| Lys 410 | - | linker |
| Asn 411 | - | linker |
| Tyr 412 | - | linker |
| His 413 | - | linker |
| Leu 414 | - | linker |
| Glu 415 | - | linker |
| Asn 416 | - | linker |
| Glu 417 | - | linker |
| Val 418 | - | linker |
| Ala 419 | - | linker |
| Arg 420 | - | linker |
| Leu 421 | - | linker |
| Lys 422 | - | linker |
| Lys 423 | - | linker |
| Leu 424 | - | linker |
| Val 425 | - | linker |
| Glu 426 | - | expression tag |
| Phe 427 | - | expression tag |
| Thr 428 | - | expression tag |
| Ser 429 | - | expression tag |
| Ala 430 | - | expression tag |
| Trp 431 | - | expression tag |
| Ser 432 | - | expression tag |
| His 433 | - | expression tag |
| Pro 434 | - | expression tag |
| Gln 435 | - | expression tag |
| Phe 436 | - | expression tag |
| Glu 437 | - | expression tag |
| Lys 438 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 199713.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2819.3 | |
| All* | Total formula weight | 202532.5 |
