8UTV
KIF1A[1-393] P305L mutant ADP bound in complex with a microtubule
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (E, A) | Tubulin alpha-1B chain | polymer | 451 | 50204.4 | 2 | UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (pig) | Alpha-tubulin ubiquitous, Tubulin K-alpha-1, Tubulin alpha-ubiquitous chain |
| 2 | C (B) | Tubulin beta-2B chain | polymer | 445 | 49999.9 | 1 | UniProt (A0A287AGU7) UniProt (by SIFTS) (A0A8D1UIR5) | Sus scrofa (pig) | |
| 3 | D (K) | Kinesin-like protein KIF1A | polymer | 438 | 49304.5 | 1 | UniProt (Q12756) Pfam (PF00225) | Homo sapiens (human) | |
| 4 | E, G (E, A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 5 | F, H (E, A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | I (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 7 | J (B) | TAXOL | non-polymer | 853.9 | 1 | Chemie (TA1) PubChem (16757828) PubChem (16760674) PubChem (4666) PubChem (21458255) PubChem (23307219) PubChem (23412627) PubChem (23636632) PubChem (24848897) PubChem (24867246) PubChem (16760177) PubChem (16742549) PubChem (44323108) PubChem (44356961) PubChem (44403716) PubChem (21733096) PubChem (23307242) PubChem (23307253) PubChem (23307913) PubChem (24754091) PubChem (46781469) PubChem (24207713) PubChem (24791027) PubChem (49868078) PubChem (25200067) PubChem (54259298) PubChem (42613129) PubChem (42620039) PubChem (44155032) PubChem (44276363) PubChem (57908851) PubChem (57946364) PubChem (44279927) PubChem (44335735) PubChem (44291178) PubChem (44328863) PubChem (44342632) PubChem (44356895) PubChem (44378736) PubChem (58803237) PubChem (59844545) PubChem (45489039) PubChem (46782671) PubChem (59904698) PubChem (60123443) PubChem (71209844) PubChem (70943371) PubChem (71096818) PubChem (53313247) PubChem (53298534) PubChem (54259297) PubChem (54259299) PubChem (57489669) PubChem (73759783) PubChem (57999380) PubChem (58460861) PubChem (58777027) PubChem (58798493) PubChem (58596717) PubChem (59048611) PubChem (59042813) PubChem (58877402) PubChem (60005248) PubChem (59873251) PubChem (59914794) PubChem (59919147) PubChem (60123436) PubChem (60011010) PubChem (60147315) PubChem (66795656) PubChem (14060298) PubChem (176586897) PubChem (177678861) PubChem (36314) PubChem (60915) PubChem (177409) PubChem (184492) PubChem (70801836) PubChem (70842048) PubChem (70848451) PubChem (70856170) PubChem (441276) PubChem (73707502) PubChem (73759704) PubChem (89493063) PubChem (89847578) PubChem (90057663) PubChem (91122402) PubChem (91885464) PubChem (5460441) PubChem (5317123) PubChem (5321715) PubChem (101920282) PubChem (5352019) PubChem (121459571) PubChem (122361554) PubChem (6604028) PubChem (6604616) PubChem (6604814) PubChem (6713921) PubChem (6915727) PubChem (124747272) PubChem (124893098) PubChem (9875988) PubChem (126968948) PubChem (129395998) PubChem (129627423) PubChem (10748131) PubChem (132517454) PubChem (11320430) PubChem (11354895) PubChem (101598423) PubChem (134368714) PubChem (118528174) PubChem (134972678) PubChem (9854162) PubChem (9897470) PubChem (10033513) PubChem (137705323) PubChem (138106885) PubChem (10485732) PubChem (140731501) PubChem (140512017) PubChem (11506104) PubChem (11828953) PubChem (124747271) PubChem (124747273) PubChem (124747274) PubChem (14060299) PubChem (14060304) PubChem (14060306) PubChem (14060309) PubChem (146034004) PubChem (15983941) PubChem (153289350) PubChem (154037993) PubChem (155982214) PubChem (159121804) PubChem (160053861) PubChem (159716711) PubChem (160171678) PubChem (160585530) PubChem (163077211) PubChem (163077212) PubChem (163077209) PubChem (163284947) PubChem (126761000) PubChem (168322423) PubChem (169917882) PubChem (171036874) PubChem (175758871) PubChem (133052515) PubChem (133640187) PubChem (134715514) PubChem (143890766) PubChem (152743329) PubChem (154828192) PubChem (144453087) PubChem (160585532) PubChem (163077210) PubChem (163077213) PubChem (163077214) PubChem (163077215) PubChem (165084161) PubChem (166711459) PubChem (167423928) PubChem (170014955) PubChem (170362150) | |||
| 8 | K (K) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) |
Sequence modifications
K: 1 - 393 (UniProt: Q12756)
| PDB | External Database | Details |
|---|---|---|
| Leu 305 | Pro 305 | engineered mutation |
| Gly 394 | - | linker |
| Ala 395 | - | linker |
| Gly 396 | - | linker |
| Val 397 | - | linker |
| Lys 398 | - | linker |
| Gln 399 | - | linker |
| Leu 400 | - | linker |
| Glu 401 | - | linker |
| Asp 402 | - | linker |
| Lys 403 | - | linker |
| Val 404 | - | linker |
| Glu 405 | - | linker |
| Glu 406 | - | linker |
| Leu 407 | - | linker |
| Ala 408 | - | linker |
| Ser 409 | - | linker |
| Lys 410 | - | linker |
| Asn 411 | - | linker |
| Tyr 412 | - | linker |
| His 413 | - | linker |
| Leu 414 | - | linker |
| Glu 415 | - | linker |
| Asn 416 | - | linker |
| Glu 417 | - | linker |
| Val 418 | - | linker |
| Ala 419 | - | linker |
| Arg 420 | - | linker |
| Leu 421 | - | linker |
| Lys 422 | - | linker |
| Lys 423 | - | linker |
| Leu 424 | - | linker |
| Val 425 | - | linker |
| Glu 426 | - | expression tag |
| Phe 427 | - | expression tag |
| Thr 428 | - | expression tag |
| Ser 429 | - | expression tag |
| Ala 430 | - | expression tag |
| Trp 431 | - | expression tag |
| Ser 432 | - | expression tag |
| His 433 | - | expression tag |
| Pro 434 | - | expression tag |
| Gln 435 | - | expression tag |
| Phe 436 | - | expression tag |
| Glu 437 | - | expression tag |
| Lys 438 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 199713.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2819.3 | |
| All* | Total formula weight | 202532.5 |
