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8UMQ

LSD1-CoREST in complex with T18, long soaking

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(B)
REST corepressor 1polymer14416459.71UniProt (Q9UKL0)
Pfam (PF20878)
Pfam (PF00249)
Homo sapiens (human)Protein CoREST
2B
(A)
Lysine-specific histone demethylase 1Apolymer87195051.61UniProt (O60341)
Pfam (PF04433)
Pfam (PF01593)
Homo sapiens (human)BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2,[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A
3C
(A)
[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,13R)-3-(3-benzamidophenyl)-1-hydroxy-10,11-dimethyl-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name)non-polymer1038.81Chemie (YAO)
Sequence modifications
B: 305 - 440 (UniProt: Q9UKL0)
PDBExternal DatabaseDetails
Gly 297-expression tag
Pro 298-expression tag
Leu 299-expression tag
Gly 300-expression tag
Ser 301-expression tag
Pro 302-expression tag
Glu 303-expression tag
Phe 304-expression tag
A: 1 - 852 (UniProt: O60341)
PDBExternal DatabaseDetails
Gly -18-expression tag
Ser -17-expression tag
Ser -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
His -10-expression tag
Ser -9-expression tag
Ser -8-expression tag
Gly -7-expression tag
Leu -6-expression tag
Val -5-expression tag
Pro -4-expression tag
Arg -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
His 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight111511.4
Non-Polymers*Number of molecules1
Total formula weight1038.8
All*Total formula weight112550.2
*Water molecules are not included.

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PDB entries from 2025-07-23

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