8UKY
Crystal structure of BAK in complex with inhibiting antibody 14G6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (L, A) | 14G6 Fab light chain | polymer | 213 | 23442.0 | 2 | Homo sapiens (human) | ||
| 2 | B, E (H, B) | 14G6 Fab heavy chain | polymer | 219 | 23042.7 | 2 | Homo sapiens (human) | ||
| 3 | C, F (C, D) | Bcl-2 homologous antagonist/killer | polymer | 170 | 19037.3 | 2 | UniProt (Q16611) Pfam (PF00452) | Homo sapiens (human) | Apoptosis regulator BAK,Bcl-2-like protein 7,Bcl2-L-7 |
| 4 | AA, G, U (B, L, A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | H, J, K (L) | ACETONITRILE | non-polymer | 41.1 | 3 | Chemie (CCN) | |||
| 6 | BA, I, L, M, Q... (D, L, H, A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 8 | Chemie (PEG) | |||
| 7 | N, Z (H, B) | TRIS-HYDROXYMETHYL-METHYL-AMMONIUM | non-polymer | 122.1 | 2 | Chemie (144) | |||
| 8 | O, P, W (H, A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 3 | Chemie (PGE) | |||
| 9 | R, T (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 10 | S (A) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 11 | CA, DA, EA, FA, GA... (L, H, C, A, B...) | water | water | 18.0 | 273 | Chemie (HOH) |
Sequence modifications
C, D: 23 - 186 (UniProt: Q16611)
| PDB | External Database | Details |
|---|---|---|
| Gly 17 | - | expression tag |
| Pro 18 | - | expression tag |
| Leu 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Ser 21 | - | expression tag |
| Met 22 | - | expression tag |
| Ser 166 | Cys 166 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 131044.1 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 2317.5 | |
| All* | Total formula weight | 133361.6 |
