8UGU
Crystal structure of the second bromodomain of human BRD2 in complex with 4IND
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Bromodomain-containing protein 2 | polymer | 115 | 13524.5 | 4 | UniProt (P25440) Pfam (PF00439) | Homo sapiens (human) | O27.1.1,Really interesting new gene 3 protein |
| 2 | E, H, I, K (A, C, D) | 2-(2-METHOXYETHOXY)ETHANOL | non-polymer | 120.1 | 4 | Chemie (PG0) | |||
| 3 | F, G, J, L (A, B, C, D) | methyl [(4S)-6-(1H-indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate | non-polymer | 415.4 | 4 | Chemie (59E) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 276 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 348 - 455 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| His 343 | - | expression tag |
| Met 344 | - | expression tag |
| Gln 345 | - | expression tag |
| Asp 346 | - | expression tag |
| Pro 347 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 54097.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2142.4 | |
| All* | Total formula weight | 56240.3 |
