8UF6

Structure of Trek-1(K2P2.1) with ML336

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Potassium channel subfamily K member 2	polymer	287	31561.8	2	UniProt (P97438) Pfam (PF07885)	Mus musculus (house mouse)	Outward rectifying potassium channel protein TREK-1,TREK-1 K(+) channel subunit,Two pore potassium channel TPKC1
2	C, J (A, B)	N-[(2,4-dichlorophenyl)methyl]-4-propanamidobenzamide	non-polymer		351.2	2	Chemie (WRZ)
3	D, E (A)	DECANE	non-polymer		142.3	2	Chemie (D10)
4	F, G, H, L, M... (A, B)	POTASSIUM ION	non-polymer		39.1	6	Chemie (K)
5	I, R (A, B)	N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE	non-polymer		537.9	2	Chemie (16C)
6	K (B)	PENTAETHYLENE GLYCOL	non-polymer		238.3	1	Chemie (1PE)
7	O, P (B)	CADMIUM ION	non-polymer		112.4	2	Chemie (CD)
8	Q (B)	DODECANE	non-polymer		170.3	1	Chemie (D12)
9	S, T (B)	N-OCTANE	non-polymer		114.2	2	Chemie (OCT)
10	U (B)	HEXADECANE	non-polymer		226.4	1	Chemie (R16)

Sequence modifications

A, B: 35 - 321 (UniProt: P97438)

PDB	External Database	Details
Arg 84	Lys 84	engineered mutation
Glu 85	Gln 85	engineered mutation
Lys 86	Thr 86	engineered mutation
Leu 88	Ile 88	engineered mutation
Arg 89	Ala 89	engineered mutation
Ala 90	Gln 90	engineered mutation
Pro 92	Ala 92	engineered mutation
Ser 95	Asn 95	engineered mutation
Asp 96	Ser 96	engineered mutation
Gln 97	Thr 97	engineered mutation
Ala 119	Asn 119	engineered mutation
Ala 300	Ser 300	engineered mutation
Ala 306	Glu 306	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	63123.7
Non-Polymers*	Number of molecules	19
	Total formula weight	3385.7
All*	Total formula weight	66509.4

*Water molecules are not included.