8UDK
Human Mitochondrial DNA Polymerase gamma R853A Ternary Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase subunit gamma-1 | polymer | 1239 | 139542.6 | 1 | UniProt (P54098) Pfam (PF18136) | Homo sapiens (human) | 3'-5' exodeoxyribonuclease,5'-deoxyribose-phosphate lyase,Mitochondrial DNA polymerase catalytic subunit,PolG-alpha |
| 2 | B, C (B, C) | DNA polymerase subunit gamma-2, mitochondrial | polymer | 485 | 54991.0 | 2 | UniProt (Q9UHN1) Pfam (PF03129) | Homo sapiens (human) | DNA polymerase gamma accessory 55 kDa subunit,p55,Mitochondrial DNA polymerase accessory subunit,MtPolB,PolG-beta |
| 3 | D (P) | DNA (24-MER) | polymer | 24 | 7341.8 | 1 | synthetic construct | ||
| 4 | E (T) | DNA (28-MER) | polymer | 28 | 8644.5 | 1 | synthetic construct | ||
| 5 | F (D) | DNA (5'-D(P*AP*AP*GP*GP*GP*CP*CP*TP*AP*TP*AP*AP*AP*A)-3') | polymer | 14 | 4321.9 | 1 | synthetic construct | ||
| 6 | G (E) | DNA (5'-D(P*TP*TP*TP*TP*AP*TP*AP*GP*GP*CP*CP*CP*TP*T)-3') | polymer | 14 | 4236.8 | 1 | synthetic construct | ||
| 7 | H (A) | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE | non-polymer | 467.2 | 1 | Chemie (DCP) |
Sequence modifications
A: 1 - 1239 (UniProt: P54098)
| PDB | External Database | Details |
|---|---|---|
| Ala 198 | Asp 198 | engineered mutation |
| Ala 200 | Glu 200 | engineered mutation |
| Ala 853 | Arg 853 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 274069.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 467.2 | |
| All* | Total formula weight | 274536.6 |
