8UCO
CryoEM structure of Komagataella pastoris Cytochrome c oxidase (9 subunits) in complex with human VMAT2 and Amphetamine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Synaptic vesicular amine transporter | polymer | 514 | 55749.4 | 1 | UniProt (Q05940) In PDB | Homo sapiens (human) | |
| 2 | a | Cytochrome c oxidase subunit 1 | polymer | 535 | 58857.4 | 1 | UniProt (F2R0K8) In PDB | Komagataella pastoris | |
| 3 | b | Cytochrome c oxidase subunit 2 | polymer | 236 | 26886.9 | 1 | Komagataella pastoris | ||
| 4 | c | Cytochrome c oxidase subunit 3 | polymer | 268 | 30561.1 | 1 | UniProt (F2R0J6) In PDB | Komagataella pastoris | |
| 5 | d | Cytochrome c oxidase subunit 4 | polymer | 117 | 12970.6 | 1 | UniProt (F2QT92) In PDB | Komagataella pastoris | |
| 6 | e | Cytochrome c oxidase subunit 5 | polymer | 124 | 14519.3 | 1 | UniProt (F2QVW8) In PDB | Komagataella pastoris | |
| 7 | f | Cytochrome c oxidase subunit 6 | polymer | 100 | 11851.1 | 1 | UniProt (F2QVA2) In PDB | Komagataella pastoris | |
| 8 | g | Cytochrome c oxidase subunit 7 | polymer | 58 | 6573.6 | 1 | UniProt (F2QS38) In PDB | Komagataella pastoris | |
| 9 | h | Cytochrome c oxidase subunit 8 | polymer | 48 | 5456.5 | 1 | UniProt (F2QRE4) In PDB | Komagataella pastoris | |
| 10 | i | Cytochrome c oxidase subunit 9 | polymer | 56 | 6490.6 | 1 | UniProt (A0A1G4KPQ9) In PDB | Komagataella pastoris | |
| 11 | A | (2S)-1-phenylpropan-2-amine | non-polymer | 135.2 | 1 | Chemie (1WE) | |||
| 12 | a | COPPER (II) ION | non-polymer | 63.5 | 1 | Chemie (CU) | |||
| 13 | a | HEME-A | non-polymer | 852.8 | 2 | Chemie (HEA) | |||
| 14 | b | DINUCLEAR COPPER ION | non-polymer | 127.1 | 1 | Chemie (CUA) | |||
| 15 | b, c, e, i | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 5 | Chemie (PTY) | |||
| 16 | d | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
a: 1 - 535 (UniProt: F2R0K8)
c: 1 - 268 (UniProt: F2R0J6)
| PDB | External Database | Details |
|---|---|---|
| Ile 4 | Met 4 | conflict |
| Ile 16 | Met 16 | conflict |
| Ile 22 | Met 22 | conflict |
| Ile 33 | Met 33 | conflict |
| Ile 37 | Met 37 | conflict |
| Ile 49 | Met 49 | conflict |
| Ile 78 | Met 78 | conflict |
| Leu 85 | Thr 85 | conflict |
| Ile 90 | Met 90 | conflict |
| Ile 121 | Met 121 | conflict |
| Ile 150 | Met 150 | conflict |
| Ile 158 | Met 158 | conflict |
| Ile 165 | Met 165 | conflict |
| Ile 168 | Met 168 | conflict |
| Ile 177 | Met 177 | conflict |
| Ile 232 | Met 232 | conflict |
| Leu 237 | Thr 237 | conflict |
| Ile 250 | Met 250 | conflict |
| Ile 256 | Met 256 | conflict |
| Ile 260 | Met 260 | conflict |
| Ile 273 | Met 273 | conflict |
| Ile 314 | Met 314 | conflict |
| Ile 320 | Met 320 | conflict |
| Ile 322 | Met 322 | conflict |
| Ile 334 | Met 334 | conflict |
| Ile 367 | Met 367 | conflict |
| Leu 401 | Thr 401 | conflict |
| Ile 402 | Met 402 | conflict |
| Ile 421 | Met 421 | conflict |
| Ile 442 | Met 442 | conflict |
| Ile 455 | Met 455 | conflict |
| Ile 462 | Met 462 | conflict |
| Ile 464 | Met 464 | conflict |
| Ile 465 | Met 465 | conflict |
| Ile 510 | Met 510 | conflict |
| Ile 515 | Met 515 | conflict |
| Leu 524 | Thr 524 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ile 45 | Met 45 | conflict |
| Ile 55 | Met 55 | conflict |
| Ile 62 | Met 62 | conflict |
| Ile 81 | Met 81 | conflict |
| Ile 89 | Met 89 | conflict |
| Ile 101 | Met 101 | conflict |
| Ile 120 | Met 120 | conflict |
| Ile 129 | Met 129 | conflict |
| Ile 132 | Met 132 | conflict |
| Ile 143 | Met 143 | conflict |
| Ile 247 | Met 247 | conflict |
| Leu 248 | Thr 248 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 229916.4 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 5767.1 | |
| All* | Total formula weight | 235683.5 |
