8UC5
Apo X-ray crystal structure of Cyclophilin D with a surface entropy reduction mutation (K175I)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (X, A, B) | Peptidyl-prolyl cis-trans isomerase F, mitochondrial | polymer | 166 | 17867.3 | 3 | UniProt (P30405) Pfam (PF00160) | Homo sapiens (human) | PPIase F,Cyclophilin D,CyP-D,CypD,Cyclophilin F,Mitochondrial cyclophilin,CyP-M,Rotamase F |
| 2 | D, E, F, G, H... (X, A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 11 | Chemie (DMS) | |||
| 3 | J, P (X, A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | K, L, Q (X, A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | T, U, V (X, A, B) | water | water | 18.0 | 349 | Chemie (HOH) |
Sequence modifications
X, A, B: 3 - 165 (UniProt: P30405)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Asn 1 | - | expression tag |
| Ala 2 | - | expression tag |
| Ile 133 | Lys 175 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 53602.0 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1011.8 | |
| All* | Total formula weight | 54613.8 |
