8UC4
Apo X-ray crystal structure of Cyclophilin D with a surface entropy reduction mutation (K175I)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Peptidyl-prolyl cis-trans isomerase F, mitochondrial | polymer | 166 | 17867.3 | 1 | UniProt (P30405) Pfam (PF00160) | Homo sapiens (human) | PPIase F,Cyclophilin D,CyP-D,CypD,Cyclophilin F,Mitochondrial cyclophilin,CyP-M,Rotamase F |
| 2 | B, E (X) | POLYETHYLENE GLYCOL (N=34) | non-polymer | 1529.8 | 2 | Chemie (15P) | |||
| 3 | C, D (X) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 4 | F (X) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | G (X) | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
X: 3 - 165 (UniProt: P30405)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Asn 1 | - | expression tag |
| Ala 2 | - | expression tag |
| Ile 133 | Lys 175 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17867.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 3294.9 | |
| All* | Total formula weight | 21162.2 |
