8UAQ
Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL018-21
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | G protein-coupled receptor kinase 5 | polymer | 598 | 68931.7 | 1 | UniProt (P34947) Pfam (PF00615) Pfam (PF00069) | Homo sapiens (human) | |
| 2 | B (A) | (3Z)-N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[(4-{[(2S)-2-(furan-2-yl)-2-hydroxyacetyl]amino}-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide | non-polymer | 542.6 | 1 | Chemie (W3F) | |||
| 3 | C (A) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A: 1 - 590 (UniProt: P34947)
| PDB | External Database | Details |
|---|---|---|
| Asn 311 | Asp 311 | engineered mutation |
| Val 591 | - | expression tag |
| Asp 592 | - | expression tag |
| His 593 | - | expression tag |
| His 594 | - | expression tag |
| His 595 | - | expression tag |
| His 596 | - | expression tag |
| His 597 | - | expression tag |
| His 598 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 68931.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 542.6 | |
| All* | Total formula weight | 69474.3 |
