8UAK
Crystal structure of the catalytic domain of human PKC alpha (D463N, V568I, S657E) in complex with Darovasertib (NVP-LXS196) at 2.82-A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein kinase C alpha type | polymer | 354 | 40681.4 | 1 | UniProt (P17252) Pfam (PF00069) Pfam (PF00433) In PDB | Homo sapiens (human) | PKC-A,PKC-alpha |
| 2 | A | (6M)-3-amino-N-[3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl]-6-[3-(trifluoromethyl)pyridin-2-yl]pyrazine-2-carboxamide | non-polymer | 472.5 | 1 | Chemie (W39) | |||
| 3 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 320 - 672 (UniProt: P17252)
| PDB | External Database | Details |
|---|---|---|
| Gly 319 | - | expression tag |
| Asn 463 | Asp 463 | engineered mutation |
| Ile 568 | Val 568 | engineered mutation |
| Glu 657 | Ser 657 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40681.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 472.5 | |
| All* | Total formula weight | 41153.9 |
